Treatment of atopic dermatitis: Recently approved drugs and advanced clinical development programs

S Müller, L Maintz, T Bieber - Allergy, 2024 - Wiley Online Library
Atopic dermatitis (AD) represents the most common skin disease characterized by
heterogeneous endophenotypes and a high disease burden. In Europe, six new systemic …

Treatable Traits in Asthma: The importance of extra-pulmonary traits-GERD, CRSwNP, Atopic Dermatitis, and Depression/Anxiety

VM McDonald, Y Hamada, A Agusti… - The Journal of Allergy and …, 2024 - Elsevier
Treatable traits is a personalised medicine approach to the management of airway disease.
Assessing traits within the three domains of pulmonary, extra pulmonary and …

Global epidemiology of atopic dermatitis: a comprehensive systematic analysis and modelling study

J Tian, D Zhang, Y Yang, Y Huang… - British Journal of …, 2024 - academic.oup.com
Background Atopic dermatitis (AD) is the leading cause of the global burden from skin
disease; no study has provided global and country-specific epidemiological estimates of AD …

Nemolizumab with concomitant topical therapy in adolescents and adults with moderate-to-severe atopic dermatitis (ARCADIA 1 and ARCADIA 2): results from two …

JI Silverberg, A Wollenberg, A Reich, D Thaçi, FJ Legat… - The Lancet, 2024 - thelancet.com
Background Nemolizumab, an interleukin (IL)-31 receptor subunit α antagonist, inhibits the
IL-31 pathway of itch and skin inflammation in atopic dermatitis. Two international phase 3 …

Atopic dermatitis: A global health perspective

O Faye, C Flohr, K Kabashima, L Ma… - Journal of the …, 2024 - Wiley Online Library
Abstract The International Society of AD (ISAD) organized a roundtable on global aspects of
AD at the WCD 2023 in Singapore. According to the Global Burden of Disease (GBD) …

[HTML][HTML] Unraveling Atopic Dermatitis: Insights into Pathophysiology, Therapeutic Advances, and Future Perspectives

A Pareek, L Kumari, A Pareek, S Chaudhary, Y Ratan… - Cells, 2024 - mdpi.com
Atopic dermatitis (AD) is an inflammatory skin condition that frequently develops before the
onset of allergic rhinitis or asthma. More than 10% of children are affected by this serious …

[HTML][HTML] Advancements in Allergen Immunotherapy for the Treatment of Atopic Dermatitis

BC Guo, KH Wu, CY Chen, WY Lin, YJ Chang… - International Journal of …, 2024 - mdpi.com
Atopic dermatitis (AD) is a chronic inflammatory skin condition that affects individuals of all
age groups, manifesting as a spectrum of symptoms varying from mild to severe. Allergen …

[HTML][HTML] Real-world use of ruxolitinib cream: safety analysis at 1 year

W Hu, M Thornton, RA Livingston - American Journal of Clinical …, 2024 - Springer
Background Ruxolitinib cream is the first topical Janus kinase (JAK) inhibitor approved in the
United States (US) for the treatment of mild to moderate atopic dermatitis and nonsegmental …

[HTML][HTML] Interpreting the relationship among itch, sleep, and work productivity in patients with moderate-to-severe atopic dermatitis: a post hoc analysis of JADE MONO …

G Yosipovitch, MJ Gooderham, S Ständer… - American journal of …, 2024 - Springer
Background Abrocitinib, an oral, once-daily Janus kinase 1-selective inhibitor, improved itch
severity, sleep, and work productivity versus placebo in patients with moderate-to-severe …

[HTML][HTML] Tissue resident cells differentiate S. aureus from S. epidermidis via IL-1β following barrier disruption in healthy human skin

JC Lang, A Brutscher, M Ehrström, K Melican - PLoS pathogens, 2024 - journals.plos.org
The Staphylococcus sp. are a dominant part of the human skin microbiome and present
across the body. Staphylococcus epidermidis is a ubiquitous skin commensal, while S …