Chromosomal instability as a driver of cancer progression
X Chen, AS Agustinus, J Li, M DiBona… - Nature Reviews …, 2024 - nature.com
Chromosomal instability (CIN) refers to an increased propensity of cells to acquire structural
and numerical chromosomal abnormalities during cell division, which contributes to tumour …
and numerical chromosomal abnormalities during cell division, which contributes to tumour …
Decoding the interplay between genetic and non-genetic drivers of metastasis
Metastasis is a multistep process by which cancer cells break away from their original
location and spread to distant organs, and is responsible for the vast majority of cancer …
location and spread to distant organs, and is responsible for the vast majority of cancer …
Loss of Kmt2c or Kmt2d drives brain metastasis via KDM6A-dependent upregulation of MMP3
Abstract KMT2C and KMT2D, encoding histone H3 lysine 4 methyltransferases, are among
the most commonly mutated genes in triple-negative breast cancer (TNBC). However, how …
the most commonly mutated genes in triple-negative breast cancer (TNBC). However, how …
KMT2 family of H3K4 methyltransferases: enzymatic activity-dependent and-independent functions
Abstract Histone-lysine N-methyltransferase 2 (KMT2) methyltransferases play critical roles
in gene regulation, cell differentiation, animal development, and human diseases. KMT2 …
in gene regulation, cell differentiation, animal development, and human diseases. KMT2 …
How important is EMT for cancer metastasis?
T Celià-Terrassa, Y Kang - PLoS biology, 2024 - journals.plos.org
Epithelial-to-mesenchymal transition (EMT), a biological phenomenon of cellular plasticity
initially reported in embryonic development, has been increasingly recognized for its …
initially reported in embryonic development, has been increasingly recognized for its …
Cell-intrinsic and microenvironmental determinants of metastatic colonization
AW Lambert, Y Zhang, RA Weinberg - Nature Cell Biology, 2024 - nature.com
Cancer metastasis is a biologically complex process that remains a major challenge in the
oncology clinic, accounting for nearly all of the mortality associated with malignant …
oncology clinic, accounting for nearly all of the mortality associated with malignant …
KMT2C and KMT2D aberrations in breast cancer
E Tinsley, P Bredin, S Toomey, BT Hennessy… - Trends in Cancer, 2024 - cell.com
Abstract KMT2C and KMT2D are histone lysine methyltransferases responsible for the
monomethylation of histone 3 lysine 4 (H3K4) residues at gene enhancer sites. KMT2C/D …
monomethylation of histone 3 lysine 4 (H3K4) residues at gene enhancer sites. KMT2C/D …
Histone demethylase PHF8 promotes prostate cancer metastasis via the E2F1–SNAI1 axis
Z Wang, P Tang, H Xiao, S Peng, J Chen… - The Journal of …, 2024 - Wiley Online Library
Metastasis is the primary culprit behind cancer‐related fatalities in multiple cancer types,
including prostate cancer. Despite great advances, the precise mechanisms underlying …
including prostate cancer. Despite great advances, the precise mechanisms underlying …
Genomic characterization reveals distinct mutational landscapes and therapeutic implications between different molecular subtypes of triple-negative breast cancer
RQ Li, L Yan, L Zhang, HX Ma, HW Wang, P Bu… - Scientific Reports, 2024 - nature.com
Triple-negative breast cancer (TNBC) has high heterogeneity, poor prognosis, and limited
treatment success. Recently, an immunohistochemistry-based surrogate classification for the …
treatment success. Recently, an immunohistochemistry-based surrogate classification for the …
NF-κB-activated oncogene inhibition strategy for cancer gene therapy
W Dai, J Wu, Y Shui, Q Wu, J Wang, X Xia - Cancer Gene Therapy, 2024 - nature.com
NF-κB is a promising target for cancer treatment because of its overactivation in almost all
cancers but countless NF-κB inhibitors rarely became clinical drugs due to side effects. In …
cancers but countless NF-κB inhibitors rarely became clinical drugs due to side effects. In …