Psoriasis is a disease involving the innate and adaptative components of the immune
system, and it is triggered by environmental factors in genetically susceptible individuals …

Newly growing evidence highlights the essential role that epitranscriptomic marks play in the
development of many cancers; however, little is known about the role and implications of …

Psoriasis is a chronic inflammatory condition characterized by systemic immune
dysregulation. Over the past several years, advances in genetics, microbiology …

In the human genome, the aminopeptidases ERAP1, ERAP2 and LNPEP lie contiguously on
chromosome 5. They share sequence homology, functions and associations with immune …

Psoriasis and atopic dermatitis fall within the category of cutaneous immune-mediated
inflammatory diseases (IMIDs). The prevalence of IMIDs is increasing in industrialized …

Psoriasis vulgaris is a chronic immune-mediated dermatological condition, resulting from an
interaction between environmental triggers and genetic susceptibilities. Alteration in the …

Psoriasis is a systemic immune-mediated chronic inflammatory disease characterized by
erythematous and scaly skin plaques affecting 3.2% of adults in the United States and up to …

Context Despite high abundance of small indels in human genomes, their precise roles and
underlying mechanisms of mutagenesis in Mendelian disorders require further investigation …

ABSTRACT Coronavirus disease 2019 (COVID-19) mainly affects the respiratory system, but
the involvement of other organ systems has also been commonly reported. Acute acro …

The M1 zinc metalloproteases ERAP1, ERAP2, and IRAP play a role in HLA-I antigen
presentation by refining the peptidome either in the ER (ERAP1 and ERAP2) or in the …