Breast cancer is a leadingcause of cancer-related deaths in women globally, with triple-
negative breast cancer (TNBC) being an aggressive subtype that lacks targeted therapies …

Sirtuins are a family of proteins with enzymatic activity. There are seven mammalian sirtuins
(SIRT1-SIRT7) that are found in different cellular compartments. They are a part of crucial …

Background Kaempferol is extracted from Hedyotis diffusa, exerting an obvious anti-cancer
effect. Here in the present study, we explored the anti-cancer effects and mechanism of …

Abstract Sirtuin 3 (SIRT3), an NAD+-dependent deacetylase, plays a key role in the
modulation of metabolic reprogramming and regulation of cell death, as well as in shaping …

Colorectal cancer (CRC) is the most common malignancy of digestive system with significant
mortality rate. CRC patients with comparable clinical symptoms or at similar stages of the …

Significant limitations of the reactive medical approach in breast cancer management are
clearly reflected by alarming statistics recorded worldwide. According to the WHO updates …

Colorectal cancer (CRC) treatment strategies encompass a triad of medical interventions:
surgery, radiotherapy, and chemotherapy. Among these, the use of chemotherapy …

It has been demonstrated that cancer stem cells (CSCs) go through metabolic changes that
differentiate them from non-CSCs. The altered metabolism of CSCs plays a vital role in …

Due to its propensity to metastasize, cancer remains one of the leading causes of death
worldwide. Thanks in part to their intrinsic low cytotoxicity, the effects of the flavonoid family …

Triple‐negative breast cancer (TNBC) is a highly aggressive and metastatic malignancy with
poor treatment outcomes. The interaction between the tumor microenvironment (TME) and …