Maturation is the last phase of heart development that prepares the organ for strong,
efficient, and persistent pumping throughout the mammal's lifespan. This process is …

Tissue development is orchestrated by the coordinated activities of both chemical and
physical regulators. While much attention has been given to the role that chemical regulators …

The discovery of human pluripotent stem cells (hPSCs), including both human embryonic
stem cells and human-induced pluripotent stem cells, has opened up novel paths for a wide …

The clinical syndrome comprising heart failure (HF) symptoms but with a left ventricular
ejection fraction (EF) that is not diminished, eg, HF with preserved EF, is increasingly the …

Background Cardiomyocytes derived from human induced pluripotent stem cells (hiPSC-
CMs) have great potential as a cell source for therapeutic applications such as regenerative …

Many genes and molecules that drive tissue patterning during organogenesis and tissue
regeneration have been discovered. Yet, we still lack a full understanding of how these …

The giant protein titin forms a unique filament network in cardiomyocytes, which engages in
both mechanical and signaling functions of the heart. TTN, which encodes titin, is also a …

Cardiomyocytes differentiated from human induced pluripotent stem cells (hiPSCs) offer
tremendous potential when used to engineer human tissues for drug screening and disease …

The thin and thick filaments of muscle sarcomeres are interconnected by the giant protein
titin, which is a scaffolding filament, signaling platform, and provider of passive tension and …

A hallmark of cardiac metabolism before birth is the predominance of carbohydrate use for
energy provision. After birth, energy substrate metabolism rapidly switches to the oxidation …