Immunity to malaria has been linked to the availability and function of helper CD4+ T cells,
cytotoxic CD8+ T cells and γδ T cells that can respond to both the asymptomatic liver stage …

Malaria is a mosquito-borne disease caused by parasites of the obligate intracellular
Apicomplexa phylum the most deadly of which, Plasmodium falciparum, prevails in Africa …

Control of intracellular parasites responsible for malaria requires host IFN-γ+ T-bet+ CD4+ T
cells (Th1 cells) with IL-10 produced by Th1 cells to mitigate the pathology induced by this …

Malaria remains a major public health threat in tropical and subtropical regions across the
world. Even though less than 1% of malaria infections are fatal, this leads to about 430,000 …

Background Delay in receiving treatment for uncomplicated malaria (UM) is often reported to
increase the risk of developing severe malaria (SM), but access to treatment remains low in …

IL-10 produced by CD4+ T cells suppresses inflammation by inhibiting T cell functions and
the upstream activities of antigen presenting cells (APCs). IL-10 was first identified in Th2 …

CD4+ T-cells have been shown to play a central role in immune control of infection with
Plasmodium parasites. At the erythrocytic stage of infection, IFN-γ production by CD4+ T …

Infection with the malaria parasite, Plasmodium, is characterized by excessive inflammation.
The establishment of a precise balance between the pro-and anti-inflammatory responses is …

The development of Th1 lymphocytes is essential for cell-mediated immunity and resistance
against intracellular pathogens. However, if left unregulated, the same response can cause …

Interferon gamma (IFN-γ) is a key mediator of inflammatory immune responses induced
primarily by interleukin-12 (IL-12). IFN-γ secretion by both innate and adaptive immune cells …