Abstract Medulloblastoma accounts for 15–20% of childhood nervous system tumours. The
risk of dying was reduced by 30% in the last twenty years. Patients are divided in risk strata …

Medulloblastoma is a malignant tumor of the cerebellum and the most frequent malignant
brain tumor in children. The standard of care consists of maximal resection surgery, followed …

Abstract The HIT-SIOP-PNET4 randomised trial for standard risk medulloblastoma
(MB)(2001–2006) included 338 patients and compared hyperfractionated and conventional …

Background: Approximately 30% of children with medulloblastoma (MB) experience
recurrence, which is usually incurable. This study compared the overall survival (OS) of …

Medulloblastoma is the most common malignant brain tumor in children. Published survival
rates for this tumor are∼ 70%; however, there is limited published information on outcome …

Opinion statement Medulloblastoma (MB) is a malignant embryonal tumor of the posterior
fossa and is the most common type of brain cancer in pediatric patients. In contrast, adult MB …

Simple Summary Patients with medulloblastoma receive treatment according to a risk
stratification, which is a combination of clinical and biological factors. To date there have …

Medulloblastoma (MB) is the most common type of brain malignancy in children. Molecular
profiling has become an important component to select patients for therapeutic approaches …

Simple Summary Medulloblastoma is the commonest malignant brain tumour of childhood.
Disease relapse following maximal multi-modal therapy including upfront craniospinal …

Abstract Background Vismodegib specifically inhibits Sonic Hedgehog (SHH). We report
results of a phase I/II evaluating vismodegib+ temozolomide (TMZ) in …