Ghrelin is a peptide predominantly produced by the stomach. Ghrelin displays strong GH-
releasing activity. This activity is mediated by the activation of the so-called GH …

Somatostatin (SST) is a well-known neuropeptide that is expressed throughout the brain. In
the cortex, SST is expressed in a subset of GABAergic neurons and is known as a protein …

In 1972, Brazeau et al. isolated somatostatin (somatotropin release-inhibiting factor, SRIF), a
cyclic polypeptide with two biologically active isoforms (SRIF-14 and SRIF-28). This event …

Dementia conditions and memory deficits of different origins (vascular, metabolic and
primary neurodegenerative such as Alzheimer's and Parkinson's diseases) are getting more …

Background Brain activity governing cognition and behaviour depends on the fine-tuned
microenvironment provided by a tightly controlled blood–brain barrier (BBB). Brain …

Somatostatin is highly expressed in mammalian brain and is involved in many brain
functions such as motor activity, sleep, sensory, and cognitive processes. Five somatostatin …

In mammalian brain, the somatostatin (SRIF: somatotropin release-inhibiting factor) family is
composed of two peptides: SRIF and cortistatin (CST), which interact with five different …

In an ever‐changing environment, animals have to continuously adapt their behaviour. The
ability to learn from experience is crucial for animals to increase their chances of survival. It …

Cortistatin (CST)-14, a neuropeptide with high homology with somatostatin (SS)-14, binds all
sst subtypes but, unlike SS, also ghrelin's receptor. In six normal adults, we studied the …

Cortistatin (CST) is a neuropeptide from the somatostatin (SRIF)/urotensin (UII) family
named after its predominantly cortical expression and ability to depress cortical activity …