The emerging role of exosome-derived non-coding RNAs in cancer biology
Q Fan, L Yang, X Zhang, X Peng, S Wei, D Su, Z Zhai… - Cancer letters, 2018 - Elsevier
Exosomes are a new means of intercellular information exchange that have aroused great
research interest. Long neglected in research, exosomes were deemed nonfunctional …
research interest. Long neglected in research, exosomes were deemed nonfunctional …
Molecular control of Rab activity by GEFs, GAPs and GDI
Rab proteins are the major regulators of vesicular trafficking in eukaryotic cells. Their activity
can be tightly controlled within cells: Regulated by guanine nucleotide exchange factors …
can be tightly controlled within cells: Regulated by guanine nucleotide exchange factors …
Better together: current insights into phagosome-lysosome fusion
JA Nguyen, RM Yates - Frontiers in immunology, 2021 - frontiersin.org
Following phagocytosis, the nascent phagosome undergoes maturation to become a
phagolysosome with an acidic, hydrolytic, and often oxidative lumen that can efficiently kill …
phagolysosome with an acidic, hydrolytic, and often oxidative lumen that can efficiently kill …
Organelle identity and the signposts for membrane traffic
Eukaryotic cells have systems of internal organelles to synthesize lipids and membrane
proteins, to release secreted proteins, to take up nutrients and to degrade membrane-bound …
proteins, to release secreted proteins, to take up nutrients and to degrade membrane-bound …
Rab GTPases and membrane identity: causal or inconsequential?
FA Barr - Journal of Cell Biology, 2013 - rupress.org
Rab GTPases are highly conserved components of vesicle trafficking pathways that help to
ensure the fusion of a vesicle with a specific target organelle membrane. Specific regulatory …
ensure the fusion of a vesicle with a specific target organelle membrane. Specific regulatory …
Rab10 GTPase regulates ER dynamics and morphology
AR English, GK Voeltz - Nature cell biology, 2013 - nature.com
We have identified Rab10 as an ER-specific Rab GTPase that regulates ER structure and
dynamics. We show that Rab10 localizes to the ER and to dynamic ER-associated structures …
dynamics. We show that Rab10 localizes to the ER and to dynamic ER-associated structures …
Rab GTPases and their interacting protein partners: Structural insights into Rab functional diversity
O Pylypenko, H Hammich, IM Yu, A Houdusse - Small GTPases, 2018 - Taylor & Francis
Rab molecular switches are key players in defining membrane identity and regulating
intracellular trafficking events in eukaryotic cells. In spite of their global structural similarity …
intracellular trafficking events in eukaryotic cells. In spite of their global structural similarity …
RabGEFs are a major determinant for specific Rab membrane targeting
Eukaryotic cells critically depend on the correct regulation of intracellular vesicular trafficking
to transport biological material. The Rab subfamily of small guanosine triphosphatases …
to transport biological material. The Rab subfamily of small guanosine triphosphatases …
Phosphatidylinositol 3, 5-bisphosphate and Fab1p/PIKfyve underPPIn endo-lysosome function
SK Dove, K Dong, T Kobayashi, FK Williams… - Biochemical …, 2009 - portlandpress.com
PtdIns (3, 5) P 2 is one of the seven regulatory PPIn (polyphosphoinositides) that are
ubiquitous in eukaryotes. It controls membrane trafficking at multiple points in the …
ubiquitous in eukaryotes. It controls membrane trafficking at multiple points in the …
Lrrk2 pathogenic substitutions in Parkinson's disease
IF Mata, JM Kachergus, JP Taylor, S Lincoln, J Aasly… - Neurogenetics, 2005 - Springer
Leucine-rich repeat kinase 2 (LRRK2) mutations have been implicated in autosomal
dominant parkinsonism, consistent with typical levodopa-responsive Parkinson's disease …
dominant parkinsonism, consistent with typical levodopa-responsive Parkinson's disease …