Pemphigus encompasses a heterogeneous group of autoimmune blistering diseases, which
affect both mucous membranes and the skin. The disease usually runs a chronic-relapsing …

Nuclear factor (NF)-κB and inhibitor of NF-κB kinase (IKK) proteins regulate many
physiological processes, including the innate-and adaptive-immune responses, cell death …

Severe or therapy-resistant asthma is increasingly recognised as a major unmet need. A
Task Force, supported by the European Respiratory Society and American Thoracic Society …

The methodology for EPOS2012 has been the same as for the other two productions.
Leaders in the field were invited to critically appraise the literature and write a report on a …

Asthma is a global health problem affecting around 300 million individuals of all ages, ethnic
groups and countries. It is estimated that around 250,000 people die prematurely each year …

Asthma and chronic rhinosinusitis with nasal polyps (CRSwNP) or without (CRSsNP) are
chronic respiratory diseases. These two disorders often co-exist based on common …

Chronic obstructive pulmonary disease is a leading global cause of morbidity and mortality
that is characterised by inexorable deterioration of small airways obstruction with …

Background Severe steroid-insensitive asthma is a substantial clinical problem. Effective
treatments are urgently required, however, their development is hampered by a lack of …

During the last decade a large number of biological agents against tumor necrosis factor-α
(TNF-α), as well as many biochemical substances and molecules specifically for the medical …

Glucocorticoids remain the frontline treatment for inflammatory disorders, yet represent a
double-edged sword with beneficial therapeutic actions alongside adverse effects, mainly in …