Angiotensin II signal transduction: an update on mechanisms of physiology and pathophysiology
The renin-angiotensin-aldosterone system plays crucial roles in cardiovascular physiology
and pathophysiology. However, many of the signaling mechanisms have been unclear. The …
and pathophysiology. However, many of the signaling mechanisms have been unclear. The …
Abdominal aortic aneurysm: update on pathogenesis and medical treatments
J Golledge - Nature Reviews Cardiology, 2019 - nature.com
Abdominal aortic aneurysm (AAA) rupture is an important cause of death in adults. Currently,
the only treatment for AAA is open or endovascular surgical repair. In most parts of the …
the only treatment for AAA is open or endovascular surgical repair. In most parts of the …
Cellular mechanisms of aortic aneurysm formation
RA Quintana, WR Taylor - Circulation Research, 2019 - Am Heart Assoc
Aortic aneurysms are a common vascular disease in Western populations that can involve
virtually any portion of the aorta. Abdominal aortic aneurysms are much more common than …
virtually any portion of the aorta. Abdominal aortic aneurysms are much more common than …
Vascular smooth muscle cells in aortic aneurysm: from genetics to mechanisms
Aortic aneurysm, including thoracic aortic aneurysm and abdominal aortic aneurysm, is the
second most prevalent aortic disease following atherosclerosis, representing the ninth …
second most prevalent aortic disease following atherosclerosis, representing the ninth …
Hyaluronan receptor LYVE-1-expressing macrophages maintain arterial tone through hyaluronan-mediated regulation of smooth muscle cell collagen
HY Lim, SY Lim, CK Tan, CH Thiam, CC Goh… - Immunity, 2018 - cell.com
The maintenance of appropriate arterial tone is critically important for normal physiological
arterial function. However, the cellular and molecular mechanisms remain poorly defined …
arterial function. However, the cellular and molecular mechanisms remain poorly defined …
The mechanism and therapy of aortic aneurysms
Aortic aneurysm is a chronic aortic disease affected by many factors. Although it is generally
asymptomatic, it poses a significant threat to human life due to a high risk of rupture …
asymptomatic, it poses a significant threat to human life due to a high risk of rupture …
CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis
Atherosclerosis is the disease process that underlies heart attack and stroke. Advanced
lesions at risk of rupture are characterized by the pathological accumulation of diseased …
lesions at risk of rupture are characterized by the pathological accumulation of diseased …
[HTML][HTML] Therapeutic aptamer targeting sclerostin loop3 for promoting bone formation without increasing cardiovascular risk in osteogenesis imperfecta mice
L Wang, Y Yu, S Ni, D Li, J Liu, D Xie, HY Chu… - Theranostics, 2022 - ncbi.nlm.nih.gov
Rationale: Sclerostin inhibition demonstrated bone anabolic potential in osteogenesis
imperfecta (OI) mice, whereas humanized therapeutic sclerostin antibody romosozumab for …
imperfecta (OI) mice, whereas humanized therapeutic sclerostin antibody romosozumab for …
Pro-efferocytic nanoparticles are specifically taken up by lesional macrophages and prevent atherosclerosis
AM Flores, N Hosseini-Nassab, KU Jarr, J Ye… - Nature …, 2020 - nature.com
Atherosclerosis is the process that underlies heart attack and stroke. A characteristic feature
of the atherosclerotic plaque is the accumulation of apoptotic cells in the necrotic core …
of the atherosclerotic plaque is the accumulation of apoptotic cells in the necrotic core …
Extracellular matrix, regional heterogeneity of the aorta, and aortic aneurysm
Aortic aneurysm is an asymptomatic disease with dire outcomes if undiagnosed. Aortic
aneurysm rupture is a significant cause of death worldwide. To date, surgical repair or …
aneurysm rupture is a significant cause of death worldwide. To date, surgical repair or …