Regulation of the DNA damage response by cyclin-dependent kinases
C Trovesi, N Manfrini, M Falcettoni… - Journal of molecular …, 2013 - Elsevier
The eukaryotic cell cycle comprises a series of events, whose ordering and correct
progression depends on the oscillating activity of cyclin-dependent kinases (Cdks), which …
progression depends on the oscillating activity of cyclin-dependent kinases (Cdks), which …
Multiple mechanisms control chromosome integrity after replication fork uncoupling and restart at irreparable UV lesions
M Lopes, M Foiani, JM Sogo - Molecular cell, 2006 - cell.com
DNA replication forks pause in front of lesions on the template, eventually leading to
cytotoxic chromosomal rearrangements. The in vivo structure of damaged eukaryotic …
cytotoxic chromosomal rearrangements. The in vivo structure of damaged eukaryotic …
Replication protein A directs loading of the DNA damage checkpoint clamp to 5′-DNA junctions
J Majka, SK Binz, MS Wold, PMJ Burgers - Journal of Biological Chemistry, 2006 - ASBMB
The heterotrimeric checkpoint clamp comprises the Saccharomyces cerevisiae Rad17,
Mec3, and Ddc1 subunits (Rad17/3/1, the 9-1-1 complex in humans). This DNA damage …
Mec3, and Ddc1 subunits (Rad17/3/1, the 9-1-1 complex in humans). This DNA damage …
The Saccharomyces cerevisiae Sae2 protein promotes resection and bridging of double strand break ends
M Clerici, D Mantiero, G Lucchini… - Journal of Biological …, 2005 - ASBMB
When eukaryotic chromosomes undergo double strand breaks (DSBs), several
evolutionarily conserved proteins, among which the MRX complex, are recruited to the break …
evolutionarily conserved proteins, among which the MRX complex, are recruited to the break …
Colocalization of sensors is sufficient to activate the DNA damage checkpoint in the absence of damage
CY Bonilla, JA Melo, DP Toczyski - Molecular cell, 2008 - cell.com
Previous work on the DNA damage checkpoint in Saccharomyces cerevisiae has shown that
two complexes independently sense DNA lesions: the kinase Mec1-Ddc2 and the PCNA …
two complexes independently sense DNA lesions: the kinase Mec1-Ddc2 and the PCNA …
Replication and recombination factors contributing to recombination-dependent bypass of DNA lesions by template switch
F Vanoli, M Fumasoni, B Szakal, L Maloisel… - PLoS …, 2010 - journals.plos.org
Damage tolerance mechanisms mediating damage-bypass and gap-filling are crucial for
genome integrity. A major damage tolerance pathway involves recombination and is …
genome integrity. A major damage tolerance pathway involves recombination and is …
Rad52‐mediated DNA annealing after Rad51‐mediated DNA strand exchange promotes second ssDNA capture
T Sugiyama, N Kantake, Y Wu… - The EMBO …, 2006 - embopress.org
Rad51, Rad52, and RPA play central roles in homologous DNA recombination. Rad51
mediates DNA strand exchange, a key reaction in DNA recombination. Rad52 has two …
mediates DNA strand exchange, a key reaction in DNA recombination. Rad52 has two …
[HTML][HTML] Dissection of DNA damage responses using multiconditional genetic interaction maps
A Guénolé, R Srivas, K Vreeken, ZZ Wang, S Wang… - Molecular cell, 2013 - cell.com
To protect the genome, cells have evolved a diverse set of pathways designed to sense,
signal, and repair multiple types of DNA damage. To assess the degree of coordination and …
signal, and repair multiple types of DNA damage. To assess the degree of coordination and …
The cellular response to chromosome breakage
MP Longhese, D Mantiero, M Clerici - Molecular microbiology, 2006 - Wiley Online Library
DNA double‐strand breaks (DSBs) are among the most deleterious types of damage that
can occur in the genome of eukaryotic cells because failure to repair them can lead to loss of …
can occur in the genome of eukaryotic cells because failure to repair them can lead to loss of …
DNA damage activates the SAC in an ATM/ATR-dependent manner, independently of the kinetochore
EM Kim, DJ Burke - PLoS genetics, 2008 - journals.plos.org
The DNA damage checkpoint and the spindle assembly checkpoint (SAC) are two important
regulatory mechanisms that respond to different lesions. The DNA damage checkpoint …
regulatory mechanisms that respond to different lesions. The DNA damage checkpoint …