Traumatic brain injury: progress and challenges in prevention, clinical care, and research
Executive summary Traumatic brain injury (TBI) has the highest incidence of all common
neurological disorders, and poses a substantial public health burden. TBI is increasingly …
neurological disorders, and poses a substantial public health burden. TBI is increasingly …
Blood phospho-tau in Alzheimer disease: analysis, interpretation, and clinical utility
Well-authenticated biomarkers can provide critical insights into the biological basis of
Alzheimer disease (AD) to enable timely and accurate diagnosis, estimate future burden and …
Alzheimer disease (AD) to enable timely and accurate diagnosis, estimate future burden and …
Brain-derived tau: a novel blood-based biomarker for Alzheimer's disease-type neurodegeneration
F Gonzalez-Ortiz, M Turton, PR Kac, D Smirnov… - Brain, 2023 - academic.oup.com
Blood-based biomarkers for amyloid beta and phosphorylated tau show good diagnostic
accuracies and agreements with their corresponding CSF and neuroimaging biomarkers in …
accuracies and agreements with their corresponding CSF and neuroimaging biomarkers in …
[HTML][HTML] Blood plasma phosphorylated-tau isoforms track CNS change in Alzheimer's disease
NR Barthélemy, K Horie, C Sato… - The Journal of …, 2020 - ncbi.nlm.nih.gov
Highly sensitive and specific plasma biomarkers for Alzheimer's disease (AD) have the
potential to improve diagnostic accuracy in the clinic and facilitate research studies including …
potential to improve diagnostic accuracy in the clinic and facilitate research studies including …
An update on diagnostic and prognostic biomarkers for traumatic brain injury
Introduction: Traumatic brain injury (TBI) is a major worldwide neurological disorder of
epidemic proportions. To date, there are still no FDA-approved therapies to treat any forms …
epidemic proportions. To date, there are still no FDA-approved therapies to treat any forms …
Traumatic brain injury and Alzheimer's disease: the cerebrovascular link
J Ramos-Cejudo, T Wisniewski, C Marmar… - …, 2018 - thelancet.com
Traumatic brain injury (TBI) and Alzheimer's disease (AD) are devastating neurological
disorders, whose complex relationship is not completely understood. Cerebrovascular …
disorders, whose complex relationship is not completely understood. Cerebrovascular …
Association between plasma GFAP concentrations and MRI abnormalities in patients with CT-negative traumatic brain injury in the TRACK-TBI cohort: a prospective …
Background After traumatic brain injury (TBI), plasma concentration of glial fibrillary acidic
protein (GFAP) correlates with intracranial injury visible on CT scan. Some patients with …
protein (GFAP) correlates with intracranial injury visible on CT scan. Some patients with …
[HTML][HTML] Biomarkers for tau pathology
The aggregation of fibrils of hyperphosphorylated and C-terminally truncated microtubule-
associated tau protein characterizes 80% of all dementia disorders, the most common …
associated tau protein characterizes 80% of all dementia disorders, the most common …
Traumatic brain injury: integrated approaches to improve prevention, clinical care, and research
Executive summary A concerted effort to tackle the global health problem posed by traumatic
brain injury (TBI) is long overdue. TBI is a public health challenge of vast, but insufficiently …
brain injury (TBI) is long overdue. TBI is a public health challenge of vast, but insufficiently …
TrkB agonist N-acetyl serotonin promotes functional recovery after traumatic brain injury by suppressing ferroptosis via the PI3K/Akt/Nrf2/Ferritin H pathway
Y Cheng, Y Gao, J Li, T Rui, Q Li, H Chen, B Jia… - Free Radical Biology …, 2023 - Elsevier
Ferroptosis is a form of regulated cell death that is mainly triggered by iron-dependent lipid
peroxidation. A growing body of evidence suggests that ferroptosis is involved in the …
peroxidation. A growing body of evidence suggests that ferroptosis is involved in the …