Protein post-translational modifications (PTMs), which are usually enzymatically catalyzed,
are major regulators of protein activity and involved in almost all celluar processes …

Proteasome inhibitors (PIs) are a fascinating class of small molecules that disrupt protein
homeostasis and are highly efficacious in the blood cancer multiple myeloma. However, PIs …

Autophagy plays a vital role in sustaining cellular homeostasis and its alterations have been
implicated in the etiology of many diseases. Drugs development targeting autophagy began …

Ubiquitination and related cellular processes control a variety of aspects in human cell
biology, and defects in these processes contribute to multiple illnesses. In recent decades …

Proteasome inhibitors such as Bortezomib represent an established type of targeted
treatment for several types of hematological malignancies, including multiple myeloma …

The effectiveness of proteasome inhibitors against solid tumors is limited as the emergence
of resistance is rapid. Although many mechanisms have been proposed and verified, no …

Mass spectrometry data on ubiquitin and ubiquitin-like modifiers are becoming increasingly
more accessible, and the coverage progressively deepen as methodologies mature. This …

Aggressive B-cell lymphomas are clinically and pathologically diverse and reflect multiple
pathways of transformation involving, among others, oncogenic signalling, lymphoma …