Although the role of type I interferon (IFN) in the protection against viral infections has been
known and studied for decades, its role in other immunologically relevant scenarios …

Publisher Summary Studies of cytotoxicity by human lymphocytes revealed not only that
both allogeneic and syngeneic tumor cells were lysed in a non-MHC-restricted fashion, but …

Human and mouse plasmacytoid dendritic cells have been shown to correspond to a
specialized cell population that produces large amounts of type I interferons in response to …

Type I Interferons (IFNs) are hallmark cytokines produced in immune responses to all
classes of pathogens. Type I IFNs can influence dendritic cell (DC) activation, maturation …

Specialized subsets of dendritic cells (DCs) provide a crucial link between the innate and
adaptive immune responses. The genetic programme that coordinates these distinct DC …

It has been 50 years since the initial descriptions of what are now known as plasmacytoid
dendritic cells (pDC) and type I IFN. pDC, which are infrequent cells found in the peripheral …

Natural killer cells are a recently discovered subpopulation of lymphoid cells that are present
in most normal individuals of a range of mammalian and avian species. Natural killer cells …

Publisher Summary This chapter focuses on the important discovery that virus-specific
cytotoxic T cells are dually specific for virus and for a self cell surface antigen encoded by …

Natural killer (NK) cells develop in the bone marrow and are known to gradually acquire the
ability to eliminate infected and malignant cells, yet the cellular stages of NK lineage …

Plasmacytoid dendritic cells (pDCs) are specialized producers of type I interferons (IFNs)
that respond to most viruses. Because of their antiviral activity and regulatory functions in …