Interleukin-1 and the inflammasome as therapeutic targets in cardiovascular disease
The intracellular sensing protein termed NLRP3 (for NACHT, LRR, and PYD domains-
containing protein 3) forms a macromolecular structure called the NLRP3 inflammasome …
containing protein 3) forms a macromolecular structure called the NLRP3 inflammasome …
Therapeutic potential of colchicine in cardiovascular medicine: a pharmacological review
Colchicine is an ancient herbal drug derived from Colchicum autumnale. It was first used to
treat familial Mediterranean fever and gout. Based on its unique efficacy as an anti …
treat familial Mediterranean fever and gout. Based on its unique efficacy as an anti …
Macrophage‐mediated cholesterol handling in atherosclerosis
DA Chistiakov, YV Bobryshev… - Journal of cellular and …, 2016 - Wiley Online Library
Formation of foam cells is a hallmark at the initial stages of atherosclerosis. Monocytes
attracted by pro‐inflammatory stimuli attach to the inflamed vascular endothelium and …
attracted by pro‐inflammatory stimuli attach to the inflamed vascular endothelium and …
[HTML][HTML] Cytokines in atherosclerosis: Key players in all stages of disease and promising therapeutic targets
Atherosclerosis, a chronic inflammatory disorder of the arteries, is responsible for most
deaths in westernized societies with numbers increasing at a marked rate in developing …
deaths in westernized societies with numbers increasing at a marked rate in developing …
The role of cytokines in the development of atherosclerosis
AR Fatkhullina, IO Peshkova, EK Koltsova - Biochemistry (Moscow), 2016 - Springer
Atherosclerosis contributes to the development of many cardiovascular diseases, which
remain the leading cause of death in developed countries. Atherosclerosis is a chronic …
remain the leading cause of death in developed countries. Atherosclerosis is a chronic …
[HTML][HTML] Foam cells in atherosclerosis
XH Yu, YC Fu, DW Zhang, K Yin, CK Tang - Clinica chimica acta, 2013 - Elsevier
Atherosclerosis is a chronic disease characterized by the deposition of excessive
cholesterol in the arterial intima. Macrophage foam cells play a critical role in the occurrence …
cholesterol in the arterial intima. Macrophage foam cells play a critical role in the occurrence …
IL-33 ameliorates Alzheimer's disease-like pathology and cognitive decline
Alzheimer's disease (AD) is a devastating condition with no known effective treatment. AD is
characterized by memory loss as well as impaired locomotor ability, reasoning, and …
characterized by memory loss as well as impaired locomotor ability, reasoning, and …
Molecular biology of atherosclerosis
PN Hopkins - Physiological reviews, 2013 - journals.physiology.org
At least 468 individual genes have been manipulated by molecular methods to study their
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …
Prognostic utility of novel biomarkers of cardiovascular stress: the Framingham Heart Study
TJ Wang, KC Wollert, MG Larson, E Coglianese… - Circulation, 2012 - Am Heart Assoc
Background—Biomarkers for predicting cardiovascular events in community-based
populations have not consistently added information to standard risk factors. A limitation of …
populations have not consistently added information to standard risk factors. A limitation of …
Recent advances on the role of cytokines in atherosclerosis
Atherosclerosis is a chronic inflammatory disease of the arterial wall driven by innate and
adaptive immune responses. Inflammation controls the development and the destabilization …
adaptive immune responses. Inflammation controls the development and the destabilization …