Neuroinflammation is a central mechanism involved in neurodegeneration as observed in
Alzheimer's disease (AD), the most prevalent form of neurodegenerative disease …

Dementia is a chronic or progressive syndrome, characterized by impaired cognitive
capacity beyond what could be considered a consequence of normal aging. It affects the …

Astrocytic contributions to Alzheimer's disease (AD) progression were, until recently, largely
overlooked. Astrocytes are integral to normal brain function and astrocyte reactivity is an …

Deficiency in cerebral amyloid β-protein (Aβ) clearance is implicated in the pathogenesis of
the common late-onset forms of Alzheimer's disease (AD). Accumulation of misfolded Aβ in …

Amyloid-β proteins (Aβ) of 42 (Aβ42) and 40 aa (Aβ40) accumulate as senile plaques (SP)
and cerebrovascular amyloid protein deposits that are defining diagnostic features of …

Alzheimer disease is characterized by the accumulation of abnormally folded protein
fragments, ie, amyloid beta peptide (Aβ) and tau that precipitate in amyloid plaques and …

The worldwide incidence of Alzheimer's disease (AD) is increasing with estimates that 115
million individuals will have AD by 2050, creating an unsustainable healthcare challenge …

There is increasing evidence that deficient clearance of β-amyloid (Aβ) contributes to its
accumulation in late-onset Alzheimer disease (AD). Several Aβ-degrading enzymes …

Amyloid-β peptide (Aβ) is still best known as a molecule to cause Alzheimer's disease (AD)
through accumulation and deposition within the frontal cortex and hippocampus in the brain …

One of the characteristic hallmarks of Alzheimer's disease (AD) is an accumulation of
amyloid β (Aβ) leading to plaque formation and toxic oligomeric Aβ complexes. Besides the …