Geroscience‐guided repurposing of FDA‐approved drugs to target aging: A proposed process and prioritization
AS Kulkarni, S Aleksic, DM Berger, F Sierra… - Aging …, 2022 - Wiley Online Library
Common chronic diseases represent the greatest driver of rising healthcare costs, as well as
declining function, independence, and quality of life. Geroscience‐guided approaches seek …
declining function, independence, and quality of life. Geroscience‐guided approaches seek …
Sex difference and benzene exposure: does it matter?
D Poli, P Mozzoni, S Pinelli, D Cavallo… - International Journal of …, 2022 - mdpi.com
Sex-related biological differences might lead to different effects in women and men when
they are exposed to risk factors. A scoping review was carried out to understand if sex could …
they are exposed to risk factors. A scoping review was carried out to understand if sex could …
Efficient SABRE-SHEATH Hyperpolarization of Potent Branched-Chain-Amino-Acid Metabolic Probe [1-13C]ketoisocaproate
Efficient 13C hyperpolarization of ketoisocaproate is demonstrated in natural isotopic
abundance and [1-13C] enriched forms via SABRE-SHEATH (Signal Amplification By …
abundance and [1-13C] enriched forms via SABRE-SHEATH (Signal Amplification By …
ARCGHR Neurons Regulate Muscle Glucose Uptake
The growth hormone receptor (GHR) is expressed in brain regions that are known to
participate in the regulation of energy homeostasis and glucose metabolism. We generated …
participate in the regulation of energy homeostasis and glucose metabolism. We generated …
Menthol flavor in E-Cigarette vapor modulates social behavior correlated with central and peripheral changes of immunometabolic signalings
Z Xu, Y Tian, AX Li, J Tang, XY Jing, C Deng… - Frontiers in Molecular …, 2022 - frontiersin.org
The use of electronic cigarette (e-cigarette) has been increasing dramatically worldwide.
More than 8,000 flavors of e-cigarettes are currently marketed and menthol is one of the …
More than 8,000 flavors of e-cigarettes are currently marketed and menthol is one of the …
Adult-Onset Transcriptomic Effects of Developmental Exposure to Benzene in Zebrafish (Danio rerio): Evaluating a Volatile Organic Compound of Concern
Urban environments are afflicted by mixtures of anthropogenic volatile organic compounds
(VOCs). VOC sources that drive human exposure include vehicle exhaust, industrial …
(VOCs). VOC sources that drive human exposure include vehicle exhaust, industrial …
Hydroquinone triggers pyroptosis and endoplasmic reticulum stress via AhR-regulated oxidative stress in human lymphocytes
X Yang, S Dong, C Li, M Li, C Xing, J He, C Peng… - Toxicology Letters, 2023 - Elsevier
Benzene is a frequent component of environmental pollution and is abundant in
petrochemicals, decorative materials, motor vehicle exhaust and cigarette smoke. Benzene …
petrochemicals, decorative materials, motor vehicle exhaust and cigarette smoke. Benzene …
In Utero Maternal Benzene Exposure Predisposes to the Metabolic Imbalance in the Offspring
L Koshko, LK Debarba, M Sacla… - Toxicological …, 2021 - academic.oup.com
Environmental chemicals play a significant role in the development of metabolic disorders,
especially when exposure occurs early in life. We have recently demonstrated that benzene …
especially when exposure occurs early in life. We have recently demonstrated that benzene …
[HTML][HTML] Intrinsic sexual dimorphism in the placenta determines the differential response to benzene exposure
Maternal immune activation (MIA) by environmental challenges is linked to severe
developmental complications, such as neurocognitive disorders, autism, and even …
developmental complications, such as neurocognitive disorders, autism, and even …
Environmental stressors and metabolic disease
K Zhang, C Liu, M Sadagurski, Q Sun - Frontiers in Endocrinology, 2023 - frontiersin.org
Environmental challenges, such as air pollution, heavy metals, climate change, and overuse
of natural resources, are closely associated with the development of modern human …
of natural resources, are closely associated with the development of modern human …