Geroscience‐guided repurposing of FDA‐approved drugs to target aging: A proposed process and prioritization

AS Kulkarni, S Aleksic, DM Berger, F Sierra… - Aging …, 2022 - Wiley Online Library
Common chronic diseases represent the greatest driver of rising healthcare costs, as well as
declining function, independence, and quality of life. Geroscience‐guided approaches seek …

Sex difference and benzene exposure: does it matter?

D Poli, P Mozzoni, S Pinelli, D Cavallo… - International Journal of …, 2022 - mdpi.com
Sex-related biological differences might lead to different effects in women and men when
they are exposed to risk factors. A scoping review was carried out to understand if sex could …

Efficient SABRE-SHEATH Hyperpolarization of Potent Branched-Chain-Amino-Acid Metabolic Probe [1-13C]ketoisocaproate

I Adelabu, MRH Chowdhury, S Nantogma, C Oladun… - Metabolites, 2023 - mdpi.com
Efficient 13C hyperpolarization of ketoisocaproate is demonstrated in natural isotopic
abundance and [1-13C] enriched forms via SABRE-SHEATH (Signal Amplification By …

ARCGHR Neurons Regulate Muscle Glucose Uptake

JBM de Lima, LK Debarba, AC Rupp, N Qi, C Ubah… - Cells, 2021 - mdpi.com
The growth hormone receptor (GHR) is expressed in brain regions that are known to
participate in the regulation of energy homeostasis and glucose metabolism. We generated …

Menthol flavor in E-Cigarette vapor modulates social behavior correlated with central and peripheral changes of immunometabolic signalings

Z Xu, Y Tian, AX Li, J Tang, XY Jing, C Deng… - Frontiers in Molecular …, 2022 - frontiersin.org
The use of electronic cigarette (e-cigarette) has been increasing dramatically worldwide.
More than 8,000 flavors of e-cigarettes are currently marketed and menthol is one of the …

Adult-Onset Transcriptomic Effects of Developmental Exposure to Benzene in Zebrafish (Danio rerio): Evaluating a Volatile Organic Compound of Concern

ML Connell, CC Wu, JR Blount, A Haimbaugh… - International journal of …, 2023 - mdpi.com
Urban environments are afflicted by mixtures of anthropogenic volatile organic compounds
(VOCs). VOC sources that drive human exposure include vehicle exhaust, industrial …

Hydroquinone triggers pyroptosis and endoplasmic reticulum stress via AhR-regulated oxidative stress in human lymphocytes

X Yang, S Dong, C Li, M Li, C Xing, J He, C Peng… - Toxicology Letters, 2023 - Elsevier
Benzene is a frequent component of environmental pollution and is abundant in
petrochemicals, decorative materials, motor vehicle exhaust and cigarette smoke. Benzene …

In Utero Maternal Benzene Exposure Predisposes to the Metabolic Imbalance in the Offspring

L Koshko, LK Debarba, M Sacla… - Toxicological …, 2021 - academic.oup.com
Environmental chemicals play a significant role in the development of metabolic disorders,
especially when exposure occurs early in life. We have recently demonstrated that benzene …

[HTML][HTML] Intrinsic sexual dimorphism in the placenta determines the differential response to benzene exposure

A Maxwell, N Adzibolosu, A Hu, Y You, PM Stemmer… - Iscience, 2023 - cell.com
Maternal immune activation (MIA) by environmental challenges is linked to severe
developmental complications, such as neurocognitive disorders, autism, and even …

Environmental stressors and metabolic disease

K Zhang, C Liu, M Sadagurski, Q Sun - Frontiers in Endocrinology, 2023 - frontiersin.org
Environmental challenges, such as air pollution, heavy metals, climate change, and overuse
of natural resources, are closely associated with the development of modern human …