Inflammation and aging: signaling pathways and intervention therapies

X Li, C Li, W Zhang, Y Wang, P Qian… - Signal Transduction and …, 2023 - nature.com
Aging is characterized by systemic chronic inflammation, which is accompanied by cellular
senescence, immunosenescence, organ dysfunction, and age-related diseases. Given the …

The chemical variability, nutraceutical value, and food-industry and cosmetic applications of citrus plants: A critical review

A Ben Hsouna, C Sadaka, I Generalić Mekinić… - Antioxidants, 2023 - mdpi.com
Citrus fruits occupy an important position in the context of the fruit trade, considering that
both fresh fruits and processed products are produced on a large scale. Citrus fruits are …

Acetylcholinesterase inhibitors in the treatment of neurodegenerative diseases and the role of acetylcholinesterase in their pathogenesis

ŁJ Walczak-Nowicka, M Herbet - International journal of molecular …, 2021 - mdpi.com
Acetylcholinesterase (AChE) plays an important role in the pathogenesis of
neurodegenerative diseases by influencing the inflammatory response, apoptosis, oxidative …

Naringenin: A prospective therapeutic agent for Alzheimer's and Parkinson's disease

A Goyal, A Verma, N Dubey, J Raghav… - Journal of Food …, 2022 - Wiley Online Library
Neurodegenerative disorders (NDs) are a cluster of progressive, severe, and disabling
disorders that affect millions of people worldwide and are on the surge. These disorders are …

Naringenin alleviates paraquat-induced dopaminergic neuronal loss in SH-SY5Y cells and a rat model of Parkinson's disease

MH Ahmad, M Fatima, M Ali, MA Rizvi, AC Mondal - Neuropharmacology, 2021 - Elsevier
Abstract Parkinson's disease (PD), a common neurodegenerative disease is characterized
by the progressive loss of dopaminergic neurons in the substantia nigra. The cause of …

[HTML][HTML] Effects of melatonin and resveratrol on recognition memory and passive avoidance performance in a mouse model of Alzheimer's disease

S Labban, BS Alghamdi, FS Alshehri, M Kurdi - Behavioural Brain …, 2021 - Elsevier
Alzheimer's disease (AD) is the foremost cause of dementia among other
neurodegenerative diseases, leading to memory loss and cognitive deficits. AD has gained …

Potential therapeutic use of plant flavonoids in AD and PD

S Meng-Zhen, L Ju, Z Lan-Chun, D Cai-Feng… - Heliyon, 2022 - cell.com
Background Millions of people suffer from Alzheimer's disease (AD) and Parkinson's
disease (PD) worldwide. Due to their complex pathology, no effective pharmacological …

Neuroprotective effect of naringin against cerebellar changes in Alzheimer's disease through modulation of autophagy, oxidative stress and tau expression: An …

HM Hassan, MR Elnagar, E Abdelrazik… - Frontiers in …, 2022 - frontiersin.org
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by gradual
cognitive decline. Strong antioxidants that inhibit free radicals, such as polyphenols, reduce …

Molecular mechanisms of aluminum neurotoxicity: Update on adverse effects and therapeutic strategies

AV Skalny, M Aschner, Y Jiang, YG Gluhcheva… - Advances in …, 2021 - Elsevier
Recent studies have demonstrated that brain may be considered as the target for aluminium
(Al) toxicity, resulting in development of neurodegenerative and neurodevelopmental …

Citrus polyphenols in brain health and disease: current perspectives

MG Pontifex, MMAH Malik, E Connell… - Frontiers in …, 2021 - frontiersin.org
In addition to essential micronutrients such as vitamin C, citrus fruits represent a
considerably rich source of non-essential bioactive compounds, in particular flavanones …