Depression is an episodic form of mental illness characterized by mood state transitions with
poorly understood neurobiological mechanisms. Antidepressants reverse the effects of …

Ayahuasca is a psychoactive brew traditionally used in indigenous and religious rituals and
ceremonies in South America for its therapeutic, psychedelic, and entheogenic effects. It is …

Individual variability of stress susceptibility led to the concept of stress resilience to adapt
well upon stressors. However, the neural mechanisms of stress resilience and its relevance …

A role for dopamine in the pathophysiology of depression was first proposed in 1975 and
reviewed 20 years ago in this journal (1). Results of pharmacological treatment with …

Background Adolescence heralds the onset of much psychopathology, which may be
conceptualized as an emergence of altered covariation between symptoms and brain …

Psycho-environmental stress-based animal models of anxiety and depression are useful for
investigating pathological mechanisms and drug development. Although several rodent …

Adaptive decision making requires the evaluation of cost-benefit tradeoffs to guide action
selection. Effort-based decision making involves weighing predicted gains against effort …

Cognitive impairment is a debilitating feature of psychiatric disorders including
schizophrenia, mood disorders and substance use disorders. Despite cognitive impairment …