[HTML][HTML] Inhibition of the fibroblast growth factor receptor (FGFR) pathway: the current landscape and barriers to clinical application

YK Chae, K Ranganath, PS Hammerman, C Vaklavas… - Oncotarget, 2017 - ncbi.nlm.nih.gov
The fibroblast growth factor/fibroblast growth factor receptor (FGF/FGFR) is a tyrosine kinase
signaling pathway that has a fundamental role in many biologic processes including …

[HTML][HTML] FGFR inhibitors in oncology: insight on the management of toxicities in clinical practice

A Kommalapati, SH Tella, M Borad, M Javle, A Mahipal - Cancers, 2021 - mdpi.com
Simple Summary FGFR inhibitors evolved as therapeutic options in cholangiocarcinoma
and urothelial malignancies. Given the implications of FGFR pathway in various …

Fibroblast growth factor signalling: from development to cancer

N Turner, R Grose - Nature Reviews Cancer, 2010 - nature.com
Fibroblast growth factors (FGFs) and their receptors control a wide range of biological
functions, regulating cellular proliferation, survival, migration and differentiation. Although …

FGF receptors: cancer biology and therapeutics

M Katoh, H Nakagama - Medicinal research reviews, 2014 - Wiley Online Library
Fibroblast growth factors (FGFs) are involved in a variety of cellular processes, such as
stemness, proliferation, anti‐apoptosis, drug resistance, and angiogenesis. Here, FGF …

Fibroblast growth factors and their receptors in cancer

J Wesche, K Haglund, EM Haugsten - Biochemical Journal, 2011 - portlandpress.com
FGFs (fibroblast growth factors) and their receptors (FGFRs) play essential roles in tightly
regulating cell proliferation, survival, migration and differentiation during development and …

[HTML][HTML] FGFR inhibitors: Effects on cancer cells, tumor microenvironment and whole-body homeostasis

M Katoh - International journal of molecular medicine, 2016 - spandidos-publications.com
Abstract Fibroblast growth factor (FGF) 2, FGF4, FGF7 and FGF20 are representative
paracrine FGFs binding to heparan-sulfate proteoglycan and fibroblast growth factor …

[HTML][HTML] Genomic aberrations in the FGFR pathway: opportunities for targeted therapies in solid tumors

R Dienstmann, J Rodon, A Prat, J Perez-Garcia… - Annals of oncology, 2014 - Elsevier
The fibroblast growth factor receptor (FGFR) cascade plays crucial roles in tumor cell
proliferation, angiogenesis, migration and survival. Accumulating evidence suggests that in …

[HTML][HTML] FGF family: from drug development to clinical application

Q Hui, Z Jin, X Li, C Liu, X Wang - International journal of molecular …, 2018 - mdpi.com
Fibroblast growth factor (FGF) belongs to a large family of growth factors. FGFs use
paracrine or endocrine signaling to mediate a myriad of biological and pathophysiological …

Roles of fibroblast growth factor receptors in carcinogenesis

EM Haugsten, A Wiedlocha, S Olsnes… - Molecular cancer research, 2010 - AACR
The fibroblast growth factor receptors (FGFR) play essential roles both during development
and in the adult. Upon ligand binding, FGFRs induce intracellular signaling networks that …

FGFR2 promotes expression of PD-L1 in colorectal cancer via the JAK/STAT3 signaling pathway

P Li, T Huang, Q Zou, D Liu, Y Wang, X Tan… - The Journal of …, 2019 - journals.aai.org
Although multidisciplinary treatment is widely applied in colorectal cancer (CRC), the
prognosis of patients with advanced CRC remains poor. Immunotherapy blocking of …