Abstract RNA polymerase II (RNA Pol II) speed or elongation rate, ie, the number of
nucleotides synthesized per unit of time, is a major determinant of transcriptome …

Cytosine methylation is a DNA modification generally associated with transcriptional
silencing. Factors that regulate methylation have been linked to human disease, yet how …

Nucleosome positioning varies between cell types. By deep sequencing cell-free DNA
(cfDNA), isolated from circulating blood plasma, we generated maps of genome-wide in vivo …

Cell-free DNA (cfDNA) is evolving into a widely used prognostic and predictive biomarker,
particularly in oncology. However, its versatile clinical use precedes a profound …

DNA methylation is a major epigenetic mark with important roles in genetic regulation.
Methylated cytosines are found primarily at CpG dinucleotides, but are also found at non …

DNA methylation is frequently described as a'silencing'epigenetic mark, and indeed this
function of 5-methylcytosine was originally proposed in the 1970s. Now, thanks to improved …

Although DNA methylation was originally thought to only affect transcription, emerging
evidence shows that it also regulates alternative splicing. Exons, and especially splice sites …

Summary N 6-methyldeoxyadenosine (6mA or m 6 A) is a DNA modification preserved in
prokaryotes to eukaryotes. It is widespread in bacteria and functions in DNA mismatch …

Nucleosome remodelers of the DDM1/Lsh family are required for DNA methylation of
transposable elements, but the reason for this is unknown. How DDM1 interacts with other …

Alternative splicing (AS) of precursor mRNAs (pre-mRNAs) from multiexon genes allows
organisms to increase their coding potential and regulate gene expression through multiple …