GPCR heteromers: An overview of their classification, function and physiological relevance
G protein-coupled receptors (GPCRs) are capable of interacting to form higher order
structures such as homomers and heteromers. Heteromerisation in particular has …
structures such as homomers and heteromers. Heteromerisation in particular has …
Haloperidol‐induced catalepsy as an animal model for parkinsonism: A systematic review of experimental studies
I Waku, MS Magalhaes, CO Alves… - European Journal of …, 2021 - Wiley Online Library
Several useful animal models for parkinsonism have been developed so far. Haloperidol‐
induced catalepsy is often used as a rodent model for the study of motor impairments …
induced catalepsy is often used as a rodent model for the study of motor impairments …
The human neuropsychiatric risk gene Drd2 is necessary for social functioning across evolutionary distant species
KGO Ike, SJC Lamers, S Kaim, SF de Boer… - Molecular …, 2024 - nature.com
The Drd2 gene, encoding the dopamine D 2 receptor (D2R), was recently indicated as a
potential target in the etiology of lowered sociability (ie, social withdrawal), a symptom of …
potential target in the etiology of lowered sociability (ie, social withdrawal), a symptom of …
Evidence for functional pre-coupled complexes of receptor heteromers and adenylyl cyclase
G protein-coupled receptors (GPCRs), G proteins and adenylyl cyclase (AC) comprise one
of the most studied transmembrane cell signaling pathways. However, it is unknown whether …
of the most studied transmembrane cell signaling pathways. However, it is unknown whether …
Essential Control of the Function of the Striatopallidal Neuron by Pre-coupled Complexes of Adenosine A2A-Dopamine D2 Receptor Heterotetramers and Adenylyl …
S Ferré, J Bonaventura, W Zhu… - Frontiers in …, 2018 - frontiersin.org
The central adenosine system and adenosine receptors play a fundamental role in the
modulation of dopaminergic neurotransmission. This is mostly achieved by the strategic co …
modulation of dopaminergic neurotransmission. This is mostly achieved by the strategic co …
Decreased striatal adenosine A2A-dopamine D2 receptor heteromerization in schizophrenia
M Valle-León, LF Callado, E Aso… - …, 2021 - nature.com
According to the adenosine hypothesis of schizophrenia, the classically associated
hyperdopaminergic state may be secondary to a loss of function of the adenosinergic …
hyperdopaminergic state may be secondary to a loss of function of the adenosinergic …
New developments on the adenosine mechanisms of the central effects of caffeine and their implications for neuropsychiatric disorders
Recent studies on interactions between striatal adenosine and dopamine and one of its
main targets, the adenosine A2A receptor–dopamine D2 receptor (A2AR–D2R) heteromer …
main targets, the adenosine A2A receptor–dopamine D2 receptor (A2AR–D2R) heteromer …
Revealing Adenosine A2A-Dopamine D2 Receptor Heteromers in Parkinson's Disease Post-Mortem Brain through a New AlphaScreen-Based Assay
V Fernández-Dueñas, M Gómez-Soler… - International Journal of …, 2019 - mdpi.com
Background: Several biophysical techniques have been successfully implemented to detect
G protein-coupled receptors (GPCRs) heteromerization. Although these approaches have …
G protein-coupled receptors (GPCRs) heteromerization. Although these approaches have …
[HTML][HTML] Unique effect of clozapine on adenosine A2A-dopamine D2 receptor heteromerization
M Valle-León, N Casajuana-Martin… - Biomedicine & …, 2023 - Elsevier
The striatal dopamine D 2 receptor (D 2 R) is generally accepted to be involved in positive
symptoms of schizophrenia and is a main target for clinically used antipsychotics. D 2 R are …
symptoms of schizophrenia and is a main target for clinically used antipsychotics. D 2 R are …
Functional and Neuroprotective Role of Striatal Adenosine A2A Receptor Heterotetramers
In the striatum, adenosine A2A receptors (A2AR) are mainly expressed within the soma and
dendrites of the striatopallidal neuron. A predominant proportion of these striatal …
dendrites of the striatopallidal neuron. A predominant proportion of these striatal …