Pharmacogenomic Impact of CYP2C19 Variation on Clopidogrel Therapy in Precision Cardiovascular Medicine
SA Brown, N Pereira - Journal of personalized medicine, 2018 - mdpi.com
Variability in response to antiplatelet therapy can be explained in part by
pharmacogenomics, particularly of the CYP450 enzyme encoded by CYP2C19. Loss-of …
pharmacogenomics, particularly of the CYP450 enzyme encoded by CYP2C19. Loss-of …
Genomics of rare genetic diseases—experiences from India
S Sivasubbu, V Scaria - Human genomics, 2019 - Springer
Home to a culturally heterogeneous population, India is also a melting pot of genetic
diversity. The population architecture characterized by multiple endogamous groups with …
diversity. The population architecture characterized by multiple endogamous groups with …
Pharmacogenomic landscape of Indian population using whole genomes
Ethnic differences in pharmacogenomic (PGx) variants have been well documented in
literature and could significantly impact variability in response and adverse events to …
literature and could significantly impact variability in response and adverse events to …
Genetic diversity of variants involved in drug response among Tunisian and Italian populations toward personalized medicine
H Jmel, S Sarno, C Giuliani, W Boukhalfa… - Scientific Reports, 2024 - nature.com
Adverse drug reactions (ADR) represent a significant contributor to morbidity and mortality,
imposing a substantial financial burden. Genetic ancestry plays a crucial role in drug …
imposing a substantial financial burden. Genetic ancestry plays a crucial role in drug …
Pharmacogenetic Landscape of DPYD Variants in South Asian Populations by Integration of Genome-Scale Data
Aim: Adverse drug reactions to 5-Fluorouracil (5-FU) is frequent and largely attributable to
genetic variations in the DPYD gene, a rate limiting enzyme that clears 5-FU. The study aims …
genetic variations in the DPYD gene, a rate limiting enzyme that clears 5-FU. The study aims …
Genome wide association study of uric acid in Indian population and interaction of identified variants with Type 2 diabetes
Abstract Abnormal level of Serum Uric Acid (SUA) is an important marker and risk factor for
complex diseases including Type 2 Diabetes. Since genetic determinant of uric acid in …
complex diseases including Type 2 Diabetes. Since genetic determinant of uric acid in …
Risk of stroke in CYP2C19 LoF polymorphism carrier coronary artery disease patients undergoing clopidogrel therapy: An ethnicity-based updated meta-analysis
Background Antiplatelet agent clopidogrel has been widely used for stroke management for
many years, although resistance to clopidogrel may increase the chance of stroke …
many years, although resistance to clopidogrel may increase the chance of stroke …
Genetic Epidemiology of Pharmacogenetic Variations in CYP2C9, CYP4F2 and VKORC1 Genes Associated with Warfarin Dosage in the Indian Population
Aim: Warfarin, a widely used anticoagulant, exhibits large interindividual variability in dose
requirements. CYP2C9 and VKORC1 polymorphisms in various ethnic groups have been …
requirements. CYP2C9 and VKORC1 polymorphisms in various ethnic groups have been …
Engineering CRISPR/Cas9 therapeutics for cancer precision medicine
The discovery of Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and
CRISPR-associated protein 9 (Cas9) technology has revolutionized field of cancer …
CRISPR-associated protein 9 (Cas9) technology has revolutionized field of cancer …
Pharmacogenomic survey of Qatari populations using whole-genome and exome sequences
The Arabs represent one of the most genetically heterogeneous populations characterized
by a high prevalence of Mendelian disorders due to consanguinity. Population-scale …
by a high prevalence of Mendelian disorders due to consanguinity. Population-scale …