The 2022 WHO classification reflects increases in the knowledge of the underlying
pathogenesis of parathyroid disease. In addition to the classic characteristic features of …

Although at the genetic level cancer is caused by diverse mutations, epigenetic
modifications are characteristic of all cancers, from apparently normal precursor tissue to …

Objective: Asymptomatic primary hyperparathyroidism (PHPT) is a common clinical problem.
The purpose of this report is to provide an update on the use of diagnostic tests for this …

Primary hyperparathyroidism (PHPT) is a common disorder in which parathyroid hormone
(PTH) is excessively secreted from one or more of the four parathyroid glands. A single …

Anaplastic thyroid carcinoma (ATC) is a frequently lethal malignancy that is often
unresponsive to available therapeutic strategies. The tumorigenesis of ATC and its …

The Polycomb Repressive Complex 2 (PRC2) is a multiprotein chromatin modifying complex
that is essential for vertebrate development and differentiation. It is composed of a trimeric …

The chromatin environment is modulated by a machinery of chromatin modifiers, required for
the specification and maintenance of cell fate. Many mutations in the machinery have been …

As CRISPR-based therapies enter the clinic, evaluation of safety remains a critical and
active area of study. Here, we employ a clinical next generation sequencing (NGS) workflow …

Congenital hydrocephalus (CH), featuring markedly enlarged brain ventricles, is thought to
arise from failed cerebrospinal fluid (CSF) homeostasis and is treated with lifelong surgical …

Atypical parathyroid adenomas represent a group of intermediate form of parathyroid
neoplasms of uncertain malignant potential which show some atypical histological features …