Lack of synergistic nephrotoxicity between vancomycin and piperacillin/tazobactam in a rat model and a confirmatory cellular model

GM Pais, J Liu, SN Avedissian, D Hiner… - Journal of …, 2020 - academic.oup.com
Background Vancomycin and piperacillin/tazobactam are reported in clinical studies to
increase acute kidney injury (AKI). However, no clinical study has demonstrated synergistic …

Evaluating and mitigating risk of acute kidney injury with the combination of vancomycin and piperacillin-tazobactam in children

EM Tillman, JL Goldman - Pediatric Drugs, 2021 - Springer
The antibiotic combination of vancomycin (VAN) and piperacillin-tazobactam (PTZ) has
been associated with an increased risk of acute kidney injury (AKI) in both adult and …

Urinary biomarker and histopathological evaluation of vancomycin and piperacillin-tazobactam nephrotoxicity in comparison with vancomycin in a rat model and a …

GM Pais, J Liu, SN Avedissian, T Xanthos, A Chalkias… - BioRxiv, 2019 - biorxiv.org
Introduction Vancomycin and piperacillin tazobactam (VAN+ TZP) are two of the most
commonly utilized antibiotics in the hospital setting and are reported in clinical studies to …