[HTML][HTML] Acute myeloid leukemia: current progress and future directions

H Kantarjian, T Kadia, C DiNardo, N Daver… - Blood cancer …, 2021 - nature.com
Progress in the understanding of the biology and therapy of acute myeloid leukemia (AML)
is occurring rapidly. Since 2017, nine agents have been approved for various indications in …

Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel

H Döhner, E Estey, D Grimwade… - Blood, The Journal …, 2017 - ashpublications.org
The first edition of the European LeukemiaNet (ELN) recommendations for diagnosis and
management of acute myeloid leukemia (AML) in adults, published in 2010, has found …

CPX-351 (cytarabine and daunorubicin) liposome for injection versus conventional cytarabine plus daunorubicin in older patients with newly diagnosed secondary …

JE Lancet, GL Uy, JE Cortes, LF Newell… - Journal of Clinical …, 2018 - ascopubs.org
Purpose CPX-351 is a dual-drug liposomal encapsulation of cytarabine and daunorubicin
that delivers a synergistic 5: 1 drug ratio into leukemia cells to a greater extent than normal …

Acute myeloid leukemia, version 3.2019, NCCN clinical practice guidelines in oncology

MS Tallman, ES Wang, JK Altman… - Journal of the National …, 2019 - jnccn.org
Acute myeloid leukemia (AML) is the most common form of acute leukemia among adults
and accounts for the largest number of annual deaths due to leukemias in the United States …

Acute myeloid leukemia, version 3.2017, NCCN clinical practice guidelines in oncology

MR O'Donnell, MS Tallman, CN Abboud… - Journal of the National …, 2017 - jnccn.org
Acute myeloid leukemia (AML) is the most common form of acute leukemia among adults
and accounts for the largest number of annual deaths due to leukemias in the United States …

An update of current treatments for adult acute myeloid leukemia

H Dombret, C Gardin - Blood, The Journal of the American …, 2016 - ashpublications.org
Recent advances in acute myeloid leukemia (AML) biology and its genetic landscape
should ultimately lead to more subset-specific AML therapies, ideally tailored to each …

Venetoclax plus intensive chemotherapy with cladribine, idarubicin, and cytarabine in patients with newly diagnosed acute myeloid leukaemia or high-risk …

TM Kadia, PK Reville, G Borthakur, M Yilmaz… - The Lancet …, 2021 - thelancet.com
Background Addition of the BCL2 inhibitor venetoclax to lower intensity therapy has been
shown to improve overall survival in older (aged 75 years or older) and unfit patients with …

De novo acute myeloid leukemia: a population‐based study of outcome in the United States based on the Surveillance, Epidemiology, and End Results (SEER) …

K Sasaki, F Ravandi, TM Kadia, CD DiNardo… - Cancer, 2021 - Wiley Online Library
Background Several important treatment and supportive care strategies have been
implemented over the past 4 decades in the management of acute myeloid leukemia (AML) …

Acute myeloid leukemia: Treatment and research outlook for 2021 and the MD Anderson approach

HM Kantarjian, TM Kadia, CD DiNardo, MA Welch… - Cancer, 2021 - Wiley Online Library
The unraveling of the pathophysiology of acute myeloid leukemia (AML) has resulted in
rapid translation of the information into clinical practice. After more than 40 years of slow …

Acute myeloid leukaemia

A Khwaja, M Bjorkholm, RE Gale, RL Levine… - Nature reviews Disease …, 2016 - nature.com
Acute myeloid leukaemia (AML) is a disorder characterized by a clonal proliferation derived
from primitive haematopoietic stem cells or progenitor cells. Abnormal differentiation of …