Antimicrobial resistance (AMR) threatens human, animal, and environmental health.
Acknowledging the urgency of addressing AMR, an opportunity exists to extend AMR action …

Severe infection represents a leading reason for admission to the intensive care unit (ICU)
while nosocomial infection can arise as a complication of care in the ICU. The mortality and …

Background Adjunctive clindamycin use is associated with survival in invasive group A
streptococcus (GAS) infections but increasing clindamycin resistance in GAS has called into …

Sepsis describes life-threatening organ dysfunction due to a dysregulated host response to
infection. It is a global health priority affecting 55 million people worldwide causing 11 …

Importance Optimal health care delivery, both now and in the future, requires a continuous
loop of knowledge generation, dissemination, and uptake on how best to provide care, not …

1. Qian ET, Casey JD, Wright A, et al; Vanderbilt Center for Learning Healthcare and the
Pragmatic Critical Care Research Group. Cefepime vs piperacillintazobactam in adults …

In this year-in-review editorial, we report on key metrics for JAMA. Based on the 2023
numbers (Table), 2-6 JAMA continues to be a global leader in publishing quality clinical …

The use of antibacterial dressings is crucial in the prevention and treatment of wound
infection in emergency situations. However, the efficacy of dressings is compromised by …

INTRODUCTION—Sepsis is a clinical syndrome characterized by systemic inflammation
due to infection. There is a continuum of severity ranging from sepsis to septic shock …

Antibiotic use is the strongest risk factor for the emergence and spread of antibiotic
resistance, a global public health crisis. 1 Mitigating this crisis must include efforts to …