Atherosclerosis: recent developments
JLM Björkegren, AJ Lusis - Cell, 2022 - cell.com
Atherosclerosis is an inflammatory disease of the large arteries that is the major cause of
cardiovascular disease (CVD) and stroke. Here, we review the current understanding of the …
cardiovascular disease (CVD) and stroke. Here, we review the current understanding of the …
Consideration of sex differences in design and reporting of experimental arterial pathology studies—statement from ATVB council
P Robinet, DM Milewicz, LA Cassis… - … , and vascular biology, 2018 - Am Heart Assoc
There are many differences in arterial diseases between men and women, including
prevalence, clinical manifestations, treatments, and prognosis. The new policy of the …
prevalence, clinical manifestations, treatments, and prognosis. The new policy of the …
Olfactory receptor 2 in vascular macrophages drives atherosclerosis by NLRP3-dependent IL-1 production
M Orecchioni, K Kobiyama, H Winkels, Y Ghosheh… - Science, 2022 - science.org
Atherosclerosis is an inflammatory disease of the artery walls and involves immune cells
such as macrophages. Olfactory receptors (OLFRs) are G protein–coupled chemoreceptors …
such as macrophages. Olfactory receptors (OLFRs) are G protein–coupled chemoreceptors …
Treatment of atherosclerosis by macrophage-biomimetic nanoparticles via targeted pharmacotherapy and sequestration of proinflammatory cytokines
C Gao, Q Huang, C Liu, CHT Kwong, L Yue… - Nature …, 2020 - nature.com
Vascular disease remains the leading cause of death and disability, the etiology of which
often involves atherosclerosis. The current treatment of atherosclerosis by pharmacotherapy …
often involves atherosclerosis. The current treatment of atherosclerosis by pharmacotherapy …
Pathogenic Autoimmunity in Atherosclerosis Evolves From Initially Protective Apolipoprotein B100–Reactive CD4+ T-Regulatory Cells
Background: Throughout the inflammatory response that accompanies atherosclerosis,
autoreactive CD4+ T-helper cells accumulate in the atherosclerotic plaque. Apolipoprotein …
autoreactive CD4+ T-helper cells accumulate in the atherosclerotic plaque. Apolipoprotein …
Increased soluble urokinase plasminogen activator levels modulate monocyte function to promote atherosclerosis
People with kidney disease are disproportionately affected by atherosclerosis for unclear
reasons. Soluble urokinase plasminogen activator receptor (suPAR) is an immune-derived …
reasons. Soluble urokinase plasminogen activator receptor (suPAR) is an immune-derived …
Animal models of atherosclerosis–supportive notes and tricks of the trade
A Gisterå, DFJ Ketelhuth, SG Malin… - Circulation …, 2022 - Am Heart Assoc
Atherosclerotic cardiovascular disease is a major cause of death among humans. Animal
models have shown that cholesterol and inflammation are causatively involved in the …
models have shown that cholesterol and inflammation are causatively involved in the …
Age-associated mitochondrial dysfunction accelerates atherogenesis
Rationale: Aging is one of the strongest risk factors for atherosclerosis. Yet whether aging
increases the risk of atherosclerosis independently of chronic hyperlipidemia is not known …
increases the risk of atherosclerosis independently of chronic hyperlipidemia is not known …
Mouse models of atherosclerosis in translational research
Atherosclerotic cardiovascular disease (CVD), the major cause of premature human
mortality, is a chronic and progressive metabolic and inflammatory disease in large-and …
mortality, is a chronic and progressive metabolic and inflammatory disease in large-and …
Novel role for caspase 1 inhibitor VX765 in suppressing NLRP3 inflammasome assembly and atherosclerosis via promoting mitophagy and efferocytosis
Y Jin, Y Liu, L Xu, J Xu, Y Xiong, Y Peng, K Ding… - Cell death & …, 2022 - nature.com
Atherosclerosis is a maladaptive chronic inflammatory disease, which remains the leading
cause of death worldwide. The NLRP3 inflammasome constitutes a major driver of …
cause of death worldwide. The NLRP3 inflammasome constitutes a major driver of …