Plant tissue culture environment as a switch-key of (epi) genetic changes

PT Bednarek, R Orłowska - Plant Cell, Tissue and Organ Culture (PCTOC), 2020 - Springer
The in vitro tissue cultures are, beyond all difficulties, an essential tool in basic research as
well as in commercial applications. Numerous works devoted to plant tissue cultures proved …

Dynamic expression of DNA methyltransferases (DNMTs) in oocytes and early embryos

F Uysal, G Akkoyunlu, S Ozturk - Biochimie, 2015 - Elsevier
Epigenetic mechanisms play critical roles in oogenesis and early embryo development in
mammals. One of these epigenetic mechanisms, DNA methylation is accomplished through …

Environmental chemical exposures and human epigenetics

L Hou, X Zhang, D Wang… - International journal of …, 2012 - academic.oup.com
Every year more than 13 million deaths worldwide are due to environmental pollutants, and
approximately 24% of diseases are caused by environmental exposures that might be …

Melatonin enhances mitochondrial biogenesis and protects against rotenone‐induced mitochondrial deficiency in early porcine embryos

YJ Niu, W Zhou, ZW Nie, KT Shin… - Journal of pineal …, 2020 - Wiley Online Library
Melatonin, a major hormone of the pineal gland, exerts many beneficial effects on
mitochondria. Several studies have shown that melatonin can protect against toxin‐induced …

An oviduct-on-a-chip provides an enhanced in vitro environment for zygote genome reprogramming

MAMM Ferraz, HS Rho, D Hemerich… - Nature …, 2018 - nature.com
Worldwide over 5 million children have been conceived using assisted reproductive
technology, and research has concentrated on increasing the likelihood of ongoing …

DNA methylation and gene expression changes derived from assisted reproductive technologies can be decreased by reproductive fluids

S Canovas, E Ivanova, R Romar, S García-Martínez… - Elife, 2017 - elifesciences.org
The number of children born since the origin of Assisted Reproductive Technologies (ART)
exceeds 5 million. The majority seem healthy, but a higher frequency of defects has been …

Extracellular vesicles and the oviduct function

EA Harris, KK Stephens, W Winuthayanon - International Journal of …, 2020 - mdpi.com
In mammals, the oviduct (or the Fallopian tube in humans) can be divided into the
infundibulum (responsible for oocyte pick-up), ampulla (site of fertilization), isthmus (where …

DNA methylation changes during preimplantation development reveal inter-species differences and reprogramming events at imprinted genes

E Ivanova, S Canovas, S Garcia-Martínez, R Romar… - Clinical …, 2020 - Springer
Preimplantation embryos experience profound resetting of epigenetic information inherited
from the gametes. Genome-wide analysis at single-base resolution has shown similarities …

Efficient production of biallelic GGTA1 knockout pigs by cytoplasmic microinjection of CRISPR/Cas9 into zygotes

B Petersen, A Frenzel, A Lucas‐Hahn… - …, 2016 - Wiley Online Library
Background Xenotransplantation is considered to be a promising solution to the growing
demand for suitable donor organs for transplantation. Despite tremendous progress in the …

Epigenetic reprogramming during spermatogenesis and male factor infertility

HM McSwiggin, AM O'doherty - Reproduction, 2018 - rep.bioscientifica.com
Infertility is an often devastating diagnosis encountered by around one in six couples who
are trying to conceive. Moving away from the long-held belief that infertility is primarily a …