A review of the microbial production of bioactive natural products and biologics

JV Pham, MA Yilma, A Feliz, MT Majid… - Frontiers in …, 2019 - frontiersin.org
A variety of organisms, such as bacteria, fungi, and plants, produce secondary metabolites,
also known as natural products. Natural products have been a prolific source and an …

Merozoite surface proteins in red blood cell invasion, immunity and vaccines against malaria

JG Beeson, DR Drew, MJ Boyle, G Feng… - FEMS microbiology …, 2016 - academic.oup.com
Malaria accounts for an enormous burden of disease globally, with Plasmodium falciparum
accounting for the majority of malaria, and P. vivax being a second important cause …

Malaria vaccines: the 60-year journey of hope and final success—lessons learned and future prospects

AA El-Moamly, MA El-Sweify - Tropical Medicine and Health, 2023 - Springer
Background The world has made great strides towards beating malaria, although about half
of the world population is still exposed to the risk of contracting malaria. Developing an …

Malaria rapid diagnostic tests: challenges and prospects

JC Mouatcho, JPD Goldring - Journal of medical …, 2013 - microbiologyresearch.org
In the last decade, there has been an upsurge of interest in developing malaria rapid
diagnostic test (RDT) kits for the detection of Plasmodium species. Three antigens …

Challenges and strategies for developing efficacious and long-lasting malaria vaccines

JG Beeson, L Kurtovic, C Dobaño, DH Opi… - Science translational …, 2019 - science.org
Although there has been major recent progress in malaria vaccine development, substantial
challenges remain for achieving highly efficacious and durable vaccines against …

Comprehensive review on various strategies for antimalarial drug discovery

M Mishra, VK Mishra, V Kashaw, AK Iyer… - European journal of …, 2017 - Elsevier
The resistance of malaria parasites to existing drugs carries on growing and progressively
limiting our ability to manage this severe disease and finally lead to a massive global health …

A phase 2b randomized, controlled trial of the efficacy of the GMZ2 malaria vaccine in African children

SB Sirima, B Mordmüller, P Milligan, UA Ngoa… - Vaccine, 2016 - Elsevier
Background GMZ2 is a recombinant protein malaria vaccine, comprising two blood-stage
antigens of Plasmodium falciparum, glutamate-rich protein and merozoite surface protein 3 …

[HTML][HTML] Recent advances in recombinant protein-based malaria vaccines

SJ Draper, E Angov, T Horii, LH Miller, P Srinivasan… - Vaccine, 2015 - Elsevier
Plasmodium parasites are the causative agent of human malaria, and the development of a
highly effective vaccine against infection, disease and transmission remains a key priority. It …

The path of malaria vaccine development: challenges and perspectives

C Arama, M Troye‐Blomberg - Journal of internal medicine, 2014 - Wiley Online Library
Malaria is a life‐threatening disease caused by parasites of the P lasmodium genus. In
many parts of the world, the parasites have developed resistance to a number of antimalarial …

Controlled human malaria infection of healthy adults with lifelong malaria exposure to assess safety, immunogenicity, and efficacy of the asexual blood stage malaria …

JC Dejon-Agobe, U Ateba-Ngoa… - Clinical Infectious …, 2019 - academic.oup.com
Background GMZ2 is a recombinant malaria vaccine inducing immune responses against
Plasmodium falciparum (Pf) merozoite surface protein-3 and glutamate-rich protein. We …