Neuropathic pain has been described as the “most terrible of all tortures which a nerve
wound may inflict” and arises as a consequence of nerve injury either of the peripheral or …

Emerging evidence suggests that chronic pain is a disease that can alter brain function.
Imaging studies have demonstrated structural remapping and functional reorganization of …

Nociception is the neuronal process of encoding noxious stimuli and could be modulated at
peripheral, spinal, brainstem, and cortical levels. At cortical levels, several areas including …

Peripheral nerve and spinal cord injuries, along with other painful syndromes such as
fibromyalgia, diabetic neuropathy, chemotherapeutic neuropathy, trigeminal neuralgia …

Background Liriope platyphylla has long been reported as a therapeutic drug for treatment
of various human chronic diseases including inflammation, diabetes, neurodegenerative …

Neuropathic pain is one of the most debilitating pain conditions, yet no therapeutic strategy
has been really effective for its treatment. Hence, a better understanding of its …

Objective To assess the cerebral blood flow (CBF) in patients with diabetic neuropathic pain,
and its changes after duloxetine therapy. Methods Using iodine-123-N-isopropyl-p …

Spinal astrocyte activation contributes to the pathogenesis of paclitaxel-induced neuropathic
pain (PINP) in animal models. We examined glial fibrillary acidic protein (GFAP; an astrocyte …

Neuropathic pain is characterized by complicated combination of positive (eg, hyperalgesia
and allodynia) and negative (eg, hypoesthesia and hypoalgesia) symptoms, and is often …

Background: The anterior cingulate cortex (ACC) has been related to the affective
component of pain. Dopaminergic mesocortical circuits, including the ACC, are able to …