The term acute-on-chronic liver failure (ACLF) defines an abrupt and life-threatening
worsening of clinical conditions in patients with cirrhosis or chronic liver disease. In recent …

The peripheral arterial vasodilation hypothesis has been most influential in the field of
cirrhosis and its complications. It has given rise to hundreds of pathophysiological studies in …

The natural history of cirrhosis is characterised by an asymptomatic compensated phase
followed by a decompensated phase, marked by the development of overt clinical signs, the …

Two distinct pulmonary vascular disorders, hepatopulmonary syndrome (HPS) and
portopulmonary hypertension (POPH) may occur as a consequence of hepatic parenchymal …

Liver disease is the twelfth commonest cause of mortality in adults in the United States,
resulting in 34,000 deaths annually from cirrhosis. 7 In addition, the rising incidence of HCC …

Objective: To establish evidence-based guidelines for the use of bedside cardiac
ultrasound, echocardiography, in the ICU and equivalent care sites. Methods: Grading of …

Immune checkpoint inhibitors (ICIs) have reshaped cancer therapy. ICIs enhance T cell
activation through various mechanisms and may help reverse the exhausted phenotype of …

Oxygen is an essential element for life and without oxygen humans can survive for few
minutes only. There should be a balance between oxygen demand and delivery in order to …

Patients with acutely decompensated cirrhosis have a dismal prognosis and frequently
progress to acute-on-chronic liver failure, which is characterised by hepatic and extrahepatic …

Cirrhosis results from progressive fibrosis and is the final outcome of all chronic liver
disease. It is among the ten leading causes of death in United States. Cirrhosis can result in …