The germinal centre B cell response to SARS-CoV-2

BJ Laidlaw, AH Ellebedy - Nature Reviews Immunology, 2022 - nature.com
The germinal centre (GC) response is critical for the generation of affinity-matured plasma
cells and memory B cells capable of mediating long-term protective immunity …

Remembrance of things past: long-term B cell memory after infection and vaccination

AKE Palm, C Henry - Frontiers in immunology, 2019 - frontiersin.org
The success of vaccines is dependent on the generation and maintenance of immunological
memory. The immune system can remember previously encountered pathogens, and …

Guidelines for the use of flow cytometry and cell sorting in immunological studies

A Cossarizza, HD Chang, A Radbruch… - European journal of …, 2019 - Wiley Online Library
These guidelines are a consensus work of a considerable number of members of the
immunology and flow cytometry community. They provide the theory and key practical …

Heterogeneous plasma cells and long-lived subsets in response to immunization, autoantigen and microbiota

X Liu, J Yao, Y Zhao, J Wang, H Qi - Nature immunology, 2022 - nature.com
Durable antibody immunity depends on long-lived plasma cells (LLPCs) that primarily reside
in the bone marrow (BM). However, due to LLPC rarity, it has not been possible to define …

Niches for hematopoietic stem cells and their progeny

Q Wei, PS Frenette - Immunity, 2018 - cell.com
Steady-state hematopoietic stem cells'(HSCs) self-renewal and differentiation toward their
mature progeny in the adult bone marrow is tightly regulated by cues from the …

The role of tumor microenvironment in multiple myeloma development and progression

A Garcia-Ortiz, Y Rodríguez-García, J Encinas… - Cancers, 2021 - mdpi.com
Simple Summary Multiple Myeloma (MM) is a hematologic malignancy caused by aberrant
plasma cell proliferation in the bone marrow (BM) and constitutes the second most common …

[HTML][HTML] Secondary influenza challenge triggers resident memory B cell migration and rapid relocation to boost antibody secretion at infected sites

AJ MacLean, N Richmond, L Koneva, M Attar… - Immunity, 2022 - cell.com
Resident memory B (BRM) cells develop and persist in the lungs of influenza-infected mice
and humans; however, their contribution to recall responses has not been defined. Here, we …

Guidelines for the use of flow cytometry and cell sorting in immunological studies

A Cossarizza, HD Chang, A Radbruch… - European journal of …, 2021 - Wiley Online Library
The third edition of Flow Cytometry Guidelines provides the key aspects to consider when
performing flow cytometry experiments and includes comprehensive sections describing …

The maintenance of memory plasma cells

L Khodadadi, Q Cheng, A Radbruch… - Frontiers in …, 2019 - frontiersin.org
It is now well accepted that plasma cells can become long-lived (memory) plasma cells and
secrete antibodies for months, years or a lifetime. However, the mechanisms involved in this …

Microbiota-driven interleukin-17-producing cells and eosinophils synergize to accelerate multiple myeloma progression

A Calcinotto, A Brevi, M Chesi, R Ferrarese… - Nature …, 2018 - nature.com
The gut microbiota has been causally linked to cancer, yet how intestinal microbes influence
progression of extramucosal tumors is poorly understood. Here we provide evidence …