The most common and increasing causes of death worldwide are cardiovascular diseases
(CVD). Taking into account the fact that diet is a key factor, it is worth exploring this aspect of …

Prospective molecular targets and therapeutic applications for ketone body metabolism
have increased exponentially in the past decade. Initially considered to be restricted in …

Myocardial damage is the most serious pathological consequence of cardiovascular
diseases and an important reason for their high mortality. In recent years, because of the …

Mitochondria are cellular organelles critical for ATP production and are particularly relevant
to cardiovascular diseases including heart failure, atherosclerosis, ischemia-reperfusion …

β-Hydroxybutyrate (βOHB) is the major ketone in the body, and it is recognized as a
metabolic energy source and an important signaling molecule. While ketone oxidation is …

Aims Cardiac energy metabolism is perturbed in ischaemic heart failure and is characterized
by a shift from mitochondrial oxidative metabolism to glycolysis. Notably, the failing heart …

MicroRNAs (miRNAs) control the expression of diverse subsets of target mRNAs, and
studies have found miRNA dysregulation in failing hearts. Expression of miR-29 is abundant …

Beyond lowering plasma glucose levels, sodium–glucose cotransporter 2 inhibitors
(SGLT2is) significantly reduce hospitalization for heart failure (HF) and retard the …

Sodium-glucose co-transporter 2 (SGLT2) inhibitors, originally used for diabetes mellitus,
are gaining more popularity for other indications, owing to their positive cardiovascular and …

The heart undergoes a dynamic maturation process following birth, in response to a wide
range of stimuli, including both physiological and pathological cues. This process entails …