Low dose radiation therapy as a potential life saving treatment for COVID-19-induced acute respiratory distress syndrome (ARDS)
The new coronavirus COVID-19 disease caused by SARS-CoV-2 was declared a global
public health emergency by WHO on Jan 30, 2020. Despite massive efforts from various …
public health emergency by WHO on Jan 30, 2020. Despite massive efforts from various …
[HTML][HTML] An update on the role of Nrf2 in respiratory disease: molecular mechanisms and therapeutic approaches
J Lee, J Jang, SM Park, SR Yang - International Journal of Molecular …, 2021 - mdpi.com
Nuclear factor erythroid 2-related factor (Nrf2) is a transcriptional activator of the cell
protection gene that binds to the antioxidant response element (ARE). Therefore, Nrf2 …
protection gene that binds to the antioxidant response element (ARE). Therefore, Nrf2 …
Application of low doses of ionizing radiation in medical therapies
JM Cuttler - Dose-response, 2020 - journals.sagepub.com
The discovery of X-rays and radioactivity in 1895/1896 triggered a flood of studies and
applications of radiation in medicine that continues to this day. They started with imaging …
applications of radiation in medicine that continues to this day. They started with imaging …
Low‐dose whole‐lung radiation for COVID‐19 pneumonia: planned day 7 interim analysis of a registered clinical trial
CB Hess, ZS Buchwald, W Stokes, TH Nasti… - Cancer, 2020 - Wiley Online Library
Background Individuals of advanced age with comorbidities face a higher risk of death from
coronavirus disease 2019 (COVID‐19), especially once they are ventilator‐dependent …
coronavirus disease 2019 (COVID‐19), especially once they are ventilator‐dependent …
[HTML][HTML] Low-dose ionizing radiation as a hormetin: experimental observations and therapeutic perspective for age-related disorders
A Vaiserman, JM Cuttler, Y Socol - Biogerontology, 2021 - Springer
Hormesis is any kind of biphasic dose-response when low doses of some agents are
beneficial while higher doses are detrimental. Radiation hormesis is the most thoroughly …
beneficial while higher doses are detrimental. Radiation hormesis is the most thoroughly …
[HTML][HTML] Hydrogen sulfide and carnosine: modulation of oxidative stress and inflammation in kidney and brain axis
V Calabrese, M Scuto, AT Salinaro, G Dionisio… - Antioxidants, 2020 - mdpi.com
Emerging evidence indicates that the dysregulation of cellular redox homeostasis and
chronic inflammatory processes are implicated in the pathogenesis of kidney and brain …
chronic inflammatory processes are implicated in the pathogenesis of kidney and brain …
Immunomodulatory low-dose whole-lung radiation for patients with coronavirus disease 2019-related pneumonia
CB Hess, TH Nasti, VR Dhere, TJ Kleber… - International Journal of …, 2021 - Elsevier
Purpose Phase 1 clinical trials have established low-dose, whole-lung radiation therapy (LD-
RT) as safe for patients with coronavirus disease 2019 (COVID-19)-related pneumonia. By …
RT) as safe for patients with coronavirus disease 2019 (COVID-19)-related pneumonia. By …
Death of the ALARA radiation protection principle as used in the medical sector
PA Oakley, DE Harrison - Dose-Response, 2020 - journals.sagepub.com
ALARA is the acronym for “As Low As Reasonably Achievable.” It is a radiation protection
concept borne from the linear no-threshold (LNT) hypothesis. There are no valid data today …
concept borne from the linear no-threshold (LNT) hypothesis. There are no valid data today …
Nrf2 activation putatively mediates clinical benefits of low-dose radiotherapy in COVID-19 pneumonia and acute respiratory distress syndrome (ARDS): Novel …
EJ Calabrese, WJ Kozumbo, R Kapoor… - Radiotherapy and …, 2021 - Elsevier
Novel mechanistic insights are discussed herein that link a single, nontoxic, low-dose
radiotherapy (LDRT) treatment (0.5–1.0 Gy) to (1) beneficial subcellular effects mediated by …
radiotherapy (LDRT) treatment (0.5–1.0 Gy) to (1) beneficial subcellular effects mediated by …
Polymer nanotherapeutics: a versatile platform for effective rheumatoid arthritis therapy
Rheumatoid arthritis is an aggressive and severely debilitating disorder that is characterized
by joint pain and cartilage damage. It restricts mobility in patients, leaving them unable to …
by joint pain and cartilage damage. It restricts mobility in patients, leaving them unable to …