Low dose radiation therapy as a potential life saving treatment for COVID-19-induced acute respiratory distress syndrome (ARDS)

G Dhawan, R Kapoor, R Dhawan, R Singh… - Radiotherapy and …, 2020 - Elsevier
The new coronavirus COVID-19 disease caused by SARS-CoV-2 was declared a global
public health emergency by WHO on Jan 30, 2020. Despite massive efforts from various …

[HTML][HTML] An update on the role of Nrf2 in respiratory disease: molecular mechanisms and therapeutic approaches

J Lee, J Jang, SM Park, SR Yang - International Journal of Molecular …, 2021 - mdpi.com
Nuclear factor erythroid 2-related factor (Nrf2) is a transcriptional activator of the cell
protection gene that binds to the antioxidant response element (ARE). Therefore, Nrf2 …

Application of low doses of ionizing radiation in medical therapies

JM Cuttler - Dose-response, 2020 - journals.sagepub.com
The discovery of X-rays and radioactivity in 1895/1896 triggered a flood of studies and
applications of radiation in medicine that continues to this day. They started with imaging …

Low‐dose whole‐lung radiation for COVID‐19 pneumonia: planned day 7 interim analysis of a registered clinical trial

CB Hess, ZS Buchwald, W Stokes, TH Nasti… - Cancer, 2020 - Wiley Online Library
Background Individuals of advanced age with comorbidities face a higher risk of death from
coronavirus disease 2019 (COVID‐19), especially once they are ventilator‐dependent …

[HTML][HTML] Low-dose ionizing radiation as a hormetin: experimental observations and therapeutic perspective for age-related disorders

A Vaiserman, JM Cuttler, Y Socol - Biogerontology, 2021 - Springer
Hormesis is any kind of biphasic dose-response when low doses of some agents are
beneficial while higher doses are detrimental. Radiation hormesis is the most thoroughly …

[HTML][HTML] Hydrogen sulfide and carnosine: modulation of oxidative stress and inflammation in kidney and brain axis

V Calabrese, M Scuto, AT Salinaro, G Dionisio… - Antioxidants, 2020 - mdpi.com
Emerging evidence indicates that the dysregulation of cellular redox homeostasis and
chronic inflammatory processes are implicated in the pathogenesis of kidney and brain …

Immunomodulatory low-dose whole-lung radiation for patients with coronavirus disease 2019-related pneumonia

CB Hess, TH Nasti, VR Dhere, TJ Kleber… - International Journal of …, 2021 - Elsevier
Purpose Phase 1 clinical trials have established low-dose, whole-lung radiation therapy (LD-
RT) as safe for patients with coronavirus disease 2019 (COVID-19)-related pneumonia. By …

Death of the ALARA radiation protection principle as used in the medical sector

PA Oakley, DE Harrison - Dose-Response, 2020 - journals.sagepub.com
ALARA is the acronym for “As Low As Reasonably Achievable.” It is a radiation protection
concept borne from the linear no-threshold (LNT) hypothesis. There are no valid data today …

Nrf2 activation putatively mediates clinical benefits of low-dose radiotherapy in COVID-19 pneumonia and acute respiratory distress syndrome (ARDS): Novel …

EJ Calabrese, WJ Kozumbo, R Kapoor… - Radiotherapy and …, 2021 - Elsevier
Novel mechanistic insights are discussed herein that link a single, nontoxic, low-dose
radiotherapy (LDRT) treatment (0.5–1.0 Gy) to (1) beneficial subcellular effects mediated by …

Polymer nanotherapeutics: a versatile platform for effective rheumatoid arthritis therapy

R Nooreen, S Nene, H Jain… - Journal of Controlled …, 2022 - Elsevier
Rheumatoid arthritis is an aggressive and severely debilitating disorder that is characterized
by joint pain and cartilage damage. It restricts mobility in patients, leaving them unable to …