Mitochondrial cristae are dynamic bioenergetic compartments whose shape changes under
different physiological conditions. Recent discoveries have unveiled the relation between …

Mitochondria form a highly interconnected tubular network throughout the cell via a dynamic
process, with mitochondrial segments fusing and breaking apart continuously. Strong …

Respiratory chain complexes assemble into functional quaternary structures called
supercomplexes (RCS) within the folds of the inner mitochondrial membrane, or cristae …

The mitochondrial membrane potential (ΔΨm) is the main driver of oxidative
phosphorylation (OXPHOS). The inner mitochondrial membrane (IMM), consisting of cristae …

Mitochondrial function is critically dependent on the folding of the mitochondrial inner
membrane into cristae; indeed, numerous human diseases are associated with aberrant …

In recent years, several studies have examined the potential associations between
mitochondrial dysfunction and neurodegenerative diseases such as multiple sclerosis (MS) …

Mitochondrial DNA instability disorders are responsible for a large clinical spectrum, among
which amyotrophic lateral sclerosis-like symptoms and frontotemporal dementia are …

Cardiac ATP production primarily depends on oxidative phosphorylation in mitochondria
and is dynamically regulated by Ca 2+ levels in the mitochondrial matrix as well as by …

Mitochondria are dynamic organelles that continually move, fuse and divide. The dynamic
balance of fusion and fission of mitochondria determines their morphology and allows their …

Apoptosis is a process of programmed cell death that serves as a major mechanism for the
precise regulation of cell numbers, and as a defense mechanism to remove unwanted and …