Binge alcohol drinking elicits persistent negative affect in mice
KM Lee, M Coehlo, HA McGregor… - Behavioural brain …, 2015 - Elsevier
Cessation from chronic alcohol abuse often produces a dysphoric state that can persist into
protracted withdrawal. This dysphoric state is theorized to function as a negative reinforcer …
protracted withdrawal. This dysphoric state is theorized to function as a negative reinforcer …
The rostromedial tegmental nucleus modulates behavioral inhibition following cocaine self-administration in rats
ML Huff, RT LaLumiere - Neuropsychopharmacology, 2015 - nature.com
Recent findings suggest that the mesolimbic dopamine neurons, known to promote cocaine-
seeking behavior, are strongly inhibited by a newly characterized region of the midbrain …
seeking behavior, are strongly inhibited by a newly characterized region of the midbrain …
On the positive and negative affective responses to cocaine and their relation to drug self-administration in rats
A Ettenberg, V Fomenko, K Kaganovsky, K Shelton… - …, 2015 - Springer
Rationale Acute cocaine administration produces an initial rewarding state followed by a
dysphoric/anxiogenic “crash.” Objective The objective of this study was to determine whether …
dysphoric/anxiogenic “crash.” Objective The objective of this study was to determine whether …
Drosophila: An Emergent Model for Delineating Interactions between the Circadian Clock and Drugs of Abuse
AK De Nobrega, LC Lyons - Neural Plasticity, 2017 - Wiley Online Library
Endogenous circadian oscillators orchestrate rhythms at the cellular, physiological, and
behavioral levels across species to coordinate activity, for example, sleep/wake cycles …
behavioral levels across species to coordinate activity, for example, sleep/wake cycles …
Noradrenergic β-receptor antagonism within the central nucleus of the amygdala or bed nucleus of the stria terminalis attenuates the negative/anxiogenic effects of …
JM Wenzel, SW Cotten, HM Dominguez… - Journal of …, 2014 - Soc Neuroscience
Cocaine has been shown to produce both initial rewarding and delayed anxiogenic effects.
Although the neurobiology of cocaine's rewarding effects has been well studied, the …
Although the neurobiology of cocaine's rewarding effects has been well studied, the …
Haloperidol–Induced catalepsy is ameliorated by deep brain stimulation of the inferior colliculus
KA Engelhardt, P Marchetta, RKW Schwarting… - Scientific Reports, 2018 - nature.com
Deep brain stimulation (DBS) has evolved as a promising alternative treatment for
Parkinson's disease (PD), but the underlying mechanisms remain poorly understood …
Parkinson's disease (PD), but the underlying mechanisms remain poorly understood …
Attenuation of the anxiogenic effects of cocaine by 5-HT1B autoreceptor stimulation in the bed nucleus of the stria terminalis of rats
AK Klein, MA Brito, S Akhavan, DR Flanagan, N Le… - …, 2017 - Springer
Rationale Cocaine produces significant aversive/anxiogenic actions whose underlying
neurobiology remains unclear. A possible substrate contributing to these actions is the …
neurobiology remains unclear. A possible substrate contributing to these actions is the …
Activation of 5-HT1B receptors in the Lateral Habenula attenuates the anxiogenic effects of cocaine
AK Klein, EM Purvis, K Ayala, L Collins, JT Krug… - Behavioural brain …, 2019 - Elsevier
Recent work has implicated the Lateral Habenula (LHb) in the production of anxiogenic and
aversive states. It is innervated by all the major monoamine neurotransmitter systems and …
aversive states. It is innervated by all the major monoamine neurotransmitter systems and …
[图书][B] Age Differences in the Manifestation & Neurobiology of Negative Affect during Alcohol Withdrawal in a Mouse Model of Binge Drinking
KM Lee - 2017 - search.proquest.com
The research presented in this dissertation characterizes the manifestation and
neurobiological underpinnings of negative affect during alcohol withdrawal in adult and …
neurobiological underpinnings of negative affect during alcohol withdrawal in adult and …
[图书][B] Binge Alcohol Drinking Elicits a Persistent Negative Affective State in Mice
KM Lee - 2014 - search.proquest.com
In alcohol-dependent humans, cessation of alcohol consumption produces a dysphoric,
anxiogenic state that can persist into protracted withdrawal. This aversive withdrawal …
anxiogenic state that can persist into protracted withdrawal. This aversive withdrawal …