The imperfect effectiveness of seasonal influenza vaccines is often blamed on antigenic
mismatch, but even when the match appears good, effectiveness can be surprisingly low …

Background Influenza vaccines require annual readministration; however, several reports
have suggested that repeated vaccination might attenuate the vaccine's effectiveness. We …

At the time of writing this commentary (February 2020), the coronavirus COVID‐19 epidemic
has already resulted in more fatalities compared with the SARS and MERS coronavirus …

Currently, licensed seasonal influenza vaccines display variable vaccine effectiveness, and
there remains a need for novel vaccine platforms capable of inducing broader responses …

This report updates the 2018–19 recommendations of the Advisory Committee on
Immunization Practices (ACIP) regarding the use of seasonal influenza vaccines in the …

The present vaccine against influenza virus has the inevitable risk of antigenic discordance
between the vaccine and the circulating strains, which diminishes vaccine efficacy. This …

Background To date, no study has examined influenza vaccine effectiveness (IVE) against
laboratory-confirmed influenza-associated hospitalizations during pregnancy. Methods The …

Immune signatures measured at baseline and immediately prior to vaccination may predict
the immune response to vaccination. Such pre-vaccine assessment might allow not only …

Studies of successive vaccination suggest that immunological memory against past
influenza viruses may limit responses to vaccines containing current strains. The impact of …

Infectious diseases are a major cause for morbidity and mortality in the older population.
Demographic changes will lead to increasing numbers of older persons over the next …