MSCs: delivery routes and engraftment, cell‐targeting strategies, and immune modulation

TJ Kean, P Lin, AI Caplan, JE Dennis - Stem cells international, 2013 - Wiley Online Library
Mesenchymal stem cells (MSCs) are currently being widely investigated both in the lab and
in clinical trials for multiple disease states. The differentiation, trophic, and …

Monocytes in coronary artery disease and atherosclerosis: where are we now?

A Ghattas, HR Griffiths, A Devitt, GYH Lip… - Journal of the American …, 2013 - jacc.org
Despite improvements in interventional and pharmacological therapy of atherosclerotic
disease, it is still the leading cause of death in the developed world. Hence, there is a need …

Dual roles of graphene oxide to attenuate inflammation and elicit timely polarization of macrophage phenotypes for cardiac repair

J Han, YS Kim, MY Lim, HY Kim, S Kong, M Kang… - Acs Nano, 2018 - ACS Publications
Development of localized inflammatory environments by M1 macrophages in the cardiac
infarction region exacerbates heart failure after myocardial infarction (MI). Therefore, the …

Direct comparison of different stem cell types and subpopulations reveals superior paracrine potency and myocardial repair efficacy with cardiosphere-derived cells

TS Li, K Cheng, K Malliaras, RR Smith, Y Zhang… - Journal of the American …, 2012 - jacc.org
Objectives: The goal of this study was to conduct a direct head-to-head comparison of
different stem cell types in vitro for various assays of potency and in vivo for functional …

Adult bone marrow cell therapy improves survival and induces long-term improvement in cardiac parameters: a systematic review and meta-analysis

V Jeevanantham, M Butler, A Saad, A Abdel-Latif… - Circulation, 2012 - Am Heart Assoc
Background—Despite rapid clinical translation and widespread enthusiasm, the therapeutic
benefits of adult bone marrow cell (BMC) transplantation in patients with ischemic heart …

[HTML][HTML] Human mesenchymal stem cell-conditioned medium improves cardiac function following myocardial infarction

L Timmers, SK Lim, IE Hoefer, F Arslan, RC Lai… - Stem cell …, 2011 - Elsevier
Recent studies suggest that the therapeutic effects of stem cell transplantation following
myocardial infarction (MI) are mediated by paracrine factors. One of the main goals in the …

[HTML][HTML] Recent advances in the diagnosis and treatment of acute myocardial infarction

K Reddy, A Khaliq, RJ Henning - World journal of cardiology, 2015 - ncbi.nlm.nih.gov
Abstract The Third Universal Definition of Myocardial Infarction (MI) requires cardiac
myocyte necrosis with an increase and/or a decrease in a patient's plasma of cardiac …

Cardioprotective microRNAs: Lessons from stem cell-derived exosomal microRNAs to treat cardiovascular disease

AS Moghaddam, JT Afshari, SA Esmaeili, E Saburi… - Atherosclerosis, 2019 - Elsevier
The stem cell-based therapy has emerged as a promising therapeutic strategy for treating
cardiovascular ischemic diseases (CVIDs), such as myocardial infarction (MI). However …

Cell therapy for cardiac repair—lessons from clinical trials

A Behfar, R Crespo-Diaz, A Terzic… - Nature Reviews …, 2014 - nature.com
The global impetus to identify curative therapies has been fuelled by the unmet needs of
patients in the context of a growing heart failure pandemic. To date, regeneration trials in …

Mesenchymal stem cell therapy: A promising cell‐based therapy for treatment of myocardial infarction

AES Shafei, MA Ali, HG Ghanem… - The journal of gene …, 2017 - Wiley Online Library
For decades, mesenchymal stem (MSCs) cells have been used for cardiovascular diseases
as regenerative therapy. This review is an attempt to summarize the types of MSCs involved …