Sirtuins are the class III of histone deacetylases whose deacetylate of histones is dependent
on nicotinamide adenine dinucleotide (NAD+). Among seven sirtuins, SIRT1 plays a critical …

The sirtuins are a family of highly conserved NAD+-dependent deacetylases that act as
cellular sensors to detect energy availability and modulate metabolic processes. Two …

Modification of histones is one of the important mechanisms of epigenetics, in which genetic
control is determined by factors other than an individual's DNA sequence. Sirtuin family …

Sirtuins are a conserved family of proteins found in all domains of life. The first known sirtuin,
Sir2 (silent information regulator 2) of Saccharomyces cerevisia e, from which the family …

Excessive reactive oxygen species (ROS) induce apoptosis and are associated with various
diseases and with aging. SIRT1 (sirtuin-1), an NAD+-dependent protein deacetylase …

Background Metabolic disorders such as obesity, insulin resistance and type 2 diabetes
mellitus (DM2) are all linked to diabetic cardiomyopathy that lead to heart failure …

Sirtuin 1 (SIRT1) is an evolutionarily conserved NAD+-dependent deacetylase that is at the
pinnacle of metabolic control, all the way from yeast to humans. SIRT1 senses changes in …

Sir2 (silent information regulator 2) is an NAD+-dependent histone deacetylase that
contributes to longevity in yeast. SIRT1, a mammalian Sir2 ortholog, deacetylates histones …

In mammals, recent studies have demonstrated that the brain, the hypothalamus in
particular, is a key bidirectional integrator of humoral and neural information from peripheral …

Histone deacetylases (HDACs)—enzymes that affect the acetylation status of histones and
other important cellular proteins—have been recognized as potentially useful therapeutic …