Abstract Immune-checkpoint inhibitors (ICIs), including anti-cytotoxic T lymphocyte antigen 4
(CTLA-4), anti-programmed cell death 1 (PD-1) and anti-programmed cell death 1 ligand 1 …

Thyroid hormones are essential for growth, neuronal development, reproduction and
regulation of energy metabolism. Hypothyroidism and hyperthyroidism are common …

Immune checkpoint inhibitors (ICIs) are the standard of care for the treatment of several
cancers. While these immunotherapies have improved patient outcomes in many clinical …

Cancer immunotherapy is an effective antitumor approach through activating immune
systems to eradicate tumors by immunotherapeutics. However, direct administration of …

Background Antibodies targeting PD-1 and its ligand PDL1 are used in cancer
immunotherapy but may lead to autoimmune diseases, including type 1 diabetes (T1D). It …

Thyroid dysfunction (TD) induced by immune checkpoint inhibitors is not sufficiently
understood. The purpose of this retrospective observational study was to identify risk factors …

Background Since 2011 six immune checkpoint inhibitors (ICI) have been approved to treat
patients with many advanced solid tumor and hematological malignancies to improve their …

The management of cancer patients has changed due to the considerably more frequent
use of immune checkpoint inhibitors (ICPIs). However, the use of ICPI has a risk of side …

Immune checkpoint blockade therapy (ICBT) targeting checkpoints, such as, cytotoxic T‐
lymphocyte associated protein‐4 (CTLA‐4), programmed death‐1 (PD‐1), or programmed …

Abstract Immune Check-Point Inhibitors (CPIs) have improved long-term patients' outcomes
in several advanced cancers. Diabetes mellitus induced by CPIs (CPI-DM) is considered the …