It is well known that neurodegenerative diseases' development and progression are
accelerated due to oxidative stress and inflammation, which result in impairment of …

Ageing is an unavoidable multi-factorial process, characterised by a gradual decrease in
physiological functionality and increasing vulnerability of the organism to environmental …

Major depressive disorder (MDD) is frequently associated with poor response to treatment.
Common antidepressants target neurotransmission and neuronal plasticity, which require …

Cognitive function decline is strictly related to age, resulting in the loss of the ability to
perform daily behaviors and is a fundamental clinical neurodegeneration symptom. It has …

Menopausal women are susceptible to osteoarthritis (OA) and memory impairment. We
hypothesised that Alzheimer's-like disease (AD) exacerbates OA and that intermittent fasting …

The current study aims to determine the potential benefits of calorie restriction (CR), one of
the most promising paradigms for life span and healthspan extension, on cognitive …

Background Ketosis has been exploited for its neuroprotective impact and treatment of
neurological conditions via ketone production. Exogenous medium-chain triglyceride (MCT) …

Alzheimer's disease (AD) is the most common type of dementia. The evolution and
aggregation of amyloid beta (β) oligomers is linked to insulin resistance in AD, which is also …

随着人类预期寿命延长, 人口老龄化问题越来越严重. 过去几十年关于衰老的研究使人们对长寿
的生物学机理有了一定的认识, 然而延长寿命应以保持老年个体健康的行为和认知功能为前提 …

Dietary interventions, such as calorie restriction and ketogenic diet, have been extensively
studied in ageing research, including in cognitive decline. Epidemiological studies indicate …