[HTML][HTML] A review of the recent development in the synthesis and biological evaluations of pyrazole derivatives
O Ebenezer, M Shapi, JA Tuszynski - Biomedicines, 2022 - mdpi.com
Pyrazoles are five-membered heterocyclic compounds that contain nitrogen. They are an
important class of compounds for drug development; thus, they have attracted much …
important class of compounds for drug development; thus, they have attracted much …
[HTML][HTML] Amino-pyrazoles in medicinal chemistry: a review
M Lusardi, A Spallarossa, C Brullo - International journal of molecular …, 2023 - mdpi.com
A pyrazole nucleus is an easy-to-prepare scaffold with large therapeutic potential.
Consequently, the search for new pyrazole-based compounds is of great interest to the …
Consequently, the search for new pyrazole-based compounds is of great interest to the …
[HTML][HTML] Heterocyclic compounds: pharmacology of pyrazole analogs from rational structural considerations
RF Costa, LC Turones, KVN Cavalcante… - Frontiers in …, 2021 - frontiersin.org
Low quality of life and life-threatening conditions often demand pharmacological screening
of lead compounds. A spectrum of pharmacological activities has been attributed to pyrazole …
of lead compounds. A spectrum of pharmacological activities has been attributed to pyrazole …
Design, synthesis and biological assessment of new selective COX-2 inhibitors including methyl sulfonyl moiety
Nonsteroidal anti-inflammatory drugs (NSAIDs) cause peptic lesions in the gastrointestinal
mucosa by inhibiting the cyclooxygenase-1 (COX-1) enzyme. Selective COX-2 inhibition …
mucosa by inhibiting the cyclooxygenase-1 (COX-1) enzyme. Selective COX-2 inhibition …
Optimization of pyrazole-based compounds with 1, 2, 4-triazole-3-thiol moiety as selective COX-2 inhibitors cardioprotective drug candidates: Design, synthesis …
The cardiovascular side effects associated with COX-2 selective drugs were the worst for
coxibs leading to their withdrawal from the market a few years after their discovery …
coxibs leading to their withdrawal from the market a few years after their discovery …
Anti-inflammatory, ulcerogenic and platelet activation evaluation of novel 1, 4-diaryl-1, 2, 3-triazole neolignan-celecoxib hybrids
JL Felipe, TB Cassamale, LD Lourenco… - Bioorganic …, 2022 - Elsevier
This study reports the synthesis of novel neolignans-celecoxib hybrids and the evaluation of
their biological activity. Analogs 8–13 (L13-L18) exhibited anti-inflammatory activity …
their biological activity. Analogs 8–13 (L13-L18) exhibited anti-inflammatory activity …
An operationally simple, one‐pot, convenient synthesis, and in vitro anti‐inflammatory activity of some new spirotriazolotriazine derivatives
The wide biological actions of triazolotriazine hybrids, benzene‐sulfonamide derivatives,
exhibit a good chance of displaying in vitro anti‐inflammatory effects. An operationally …
exhibit a good chance of displaying in vitro anti‐inflammatory effects. An operationally …
Small molecule compounds with good anti-inflammatory activity reported in the literature from 01/2009 to 05/2021: a review
M Bian, Q Ma, Y Wu, H Du… - Journal of enzyme …, 2021 - Taylor & Francis
Inflammation and disease are closely related. Inflammation can induce various diseases,
and diseases can promote inflammatory response, and two possibly induces each other in a …
and diseases can promote inflammatory response, and two possibly induces each other in a …
New ursolic acid derivatives bearing 1, 2, 3-triazole moieties: design, synthesis and anti-inflammatory activity in vitro and in vivo
TY Zhang, CS Li, LT Cao, XQ Bai, DH Zhao, SM Sun - Molecular Diversity, 2022 - Springer
In order to discover novel anti-inflammatory agents, three series of compounds obtained by
appending 1, 2, 3-triazole moieties on ursolic acid were designed and synthesized. All …
appending 1, 2, 3-triazole moieties on ursolic acid were designed and synthesized. All …
Design, synthesis, biological evaluation and in silico studies of novel pyrrolo [3, 4-d] pyridazinone derivatives with promising anti-inflammatory and antioxidant activity
Ł Szczukowski, A Redzicka, B Wiatrak, E Krzyżak… - Bioorganic …, 2020 - Elsevier
Novel Mannich base analogues of pyrrolo [3, 4-d] pyridazinone 7a, b-13a, b are designed
and synthesized as potential anti-inflammatory agents. The title compounds are obtained via …
and synthesized as potential anti-inflammatory agents. The title compounds are obtained via …