The biofilm matrix: multitasking in a shared space

HC Flemming, ED van Hullebusch, TR Neu… - Nature Reviews …, 2023 - nature.com
The biofilm matrix can be considered to be a shared space for the encased microbial cells,
comprising a wide variety of extracellular polymeric substances (EPS), such as …

[HTML][HTML] Pseudomonas aeruginosa Biofilms

MTT Thi, D Wibowo, BHA Rehm - International journal of molecular …, 2020 - mdpi.com
Pseudomonas aeruginosa is an opportunistic human pathogen causing devastating acute
and chronic infections in individuals with compromised immune systems. Its highly notorious …

Pseudomonas aeruginosa adaptation and evolution in patients with cystic fibrosis

E Rossi, R La Rosa, JA Bartell, RL Marvig… - Nature Reviews …, 2021 - nature.com
Intense genome sequencing of Pseudomonas aeruginosa isolates from cystic fibrosis (CF)
airways has shown inefficient eradication of the infecting bacteria, as well as previously …

[HTML][HTML] Biofilms as promoters of bacterial antibiotic resistance and tolerance

C Uruén, G Chopo-Escuin, J Tommassen… - Antibiotics, 2020 - mdpi.com
Multidrug resistant bacteria are a global threat for human and animal health. However, they
are only part of the problem of antibiotic failure. Another bacterial strategy that contributes to …

Synthetic glycans to improve current glycoconjugate vaccines and fight antimicrobial resistance

L Del Bino, KE Østerlid, DY Wu, F Nonne… - Chemical …, 2022 - ACS Publications
Antimicrobial resistance (AMR) is emerging as the next potential pandemic. Different
microorganisms, including the bacteria Acinetobacter baumannii, Clostridioides difficile …

[HTML][HTML] Biofilms: the microbial “protective clothing” in extreme environments

W Yin, Y Wang, L Liu, J He - International journal of molecular sciences, 2019 - mdpi.com
Microbial biofilms are communities of aggregated microbial cells embedded in a self-
produced matrix of extracellular polymeric substances (EPS). Biofilms are recalcitrant to …

Atomic-level design of metalloenzyme-like active pockets in metal–organic frameworks for bioinspired catalysis

W Xu, Y Wu, W Gu, D Du, Y Lin, C Zhu - Chemical Society Reviews, 2024 - pubs.rsc.org
Natural metalloenzymes with astonishing reaction activity and specificity underpin essential
life transformations. Nevertheless, enzymes only operate under mild conditions to keep …

[HTML][HTML] Bacterial biopolymers: from pathogenesis to advanced materials

MF Moradali, BHA Rehm - Nature Reviews Microbiology, 2020 - nature.com
Bacteria are prime cell factories that can efficiently convert carbon and nitrogen sources into
a large diversity of intracellular and extracellular biopolymers, such as polysaccharides …

[HTML][HTML] Surviving as a community: antibiotic tolerance and persistence in bacterial biofilms

J Yan, BL Bassler - Cell host & microbe, 2019 - cell.com
Biofilms are surface-associated bacterial communities that play both beneficial and harmful
roles in nature, medicine, and industry. Tolerant and persister cells are thought to underlie …

[HTML][HTML] Mimicking biofilm formation and development: Recent progress in in vitro and in vivo biofilm models

I Guzmán-Soto, C McTiernan, M Gonzalez-Gomez… - Iscience, 2021 - cell.com
Biofilm formation in living organisms is associated to tissue and implant infections, and it has
also been linked to the contribution of antibiotic resistance. Thus, understanding biofilm …