Gastro-oesophageal reflux disease (GERD) is a common disorder in adults and children.
The global prevalence of GERD is high and increasing. Non-erosive reflux disease is the …

Nociceptor inputs can trigger a prolonged but reversible increase in the excitability and
synaptic efficacy of neurons in central nociceptive pathways, the phenomenon of central …

Up to 40% of patients with symptoms suspicious of gastroesophageal reflux disease (GERD)
do not respond completely to proton pump inhibitor (PPI) therapy. The term “refractory …

Gastroesophageal reflux disease (GERD) is now one of the most common diagnoses made
in a gastroenterology practice. From a conventional pathophysiological perspective, GERD …

Approximately a third of patients with suspected gastro-oesophageal reflux disease are
resistant or partial responders to proton pump inhibitors (PPIs). Many of these patients do …

Gastroesophageal reflux disease (GERD) is defined by the presence of symptoms induced
by the reflux of the stomach contents into the esophagus. Although clinical manifestations of …

Key Clinical Points Gastroesophageal Reflux Disease Patients with heartburn and
symptoms such as dysphagia, odynophagia, weight loss, anorexia, gastrointestinal …

Noncardiac chest pain (NCCP) is very common in the general population; however, a
patient's history and characteristics do not reliably distinguish between cardiac and …

Background The use of high-resolution manometry (HRM) to diagnose oesophageal motility
disorders is based on ten single water swallows (SWS); however, this approach might not be …

▪ Abstract Angina pectoris often results from ischemic episodes that excite chemosensitive
and mechanoreceptive receptors in the heart. Ischemic episodes release a collage of …