The reaction products of electrophiles in vivo can be measured as adducts to the abundant
proteins, hemoglobin (Hb), and human serum albumin (HSA), in human blood samples …

Chemicals are measured regularly in air, food, the environment, and the workplace.
Biomonitoring of chemicals in biological fluids is a tool to determine the individual exposure …

We report the design, synthesis, and evaluation of novel 5-fluorouracil (5FU) prodrugs 1a,
1b that are efficiently activated by the high level of reactive oxygen species (ROS) in cancer …

Methomyl,(E, Z)-methyl N-{[(methylamino) carbonyl] oxy} ethanimidothioate, is a widely used
pesticide that has been detected in many fatal cases of accidental exposure or suicide …

Proteins contain many sites that are subject to modification by electrophiles. Detection and
characterisation of these modifications can give insights into environmental agents and …

Analytical methods and tools for the characterization of the human exposome by untargeted
mass spectrometry approaches are advancing rapidly. Adductomics methods have been …

Adductomics is epidemiology at the molecular level. Untargeted adductomics compares
levels of chemical adducts on albumin, hemoglobin, and DNA between healthy and …

Oxime-type carbamate pesticides having an oxime moiety such as aldicarb, butocarboxim,
methomyl, oxamyl, and thiofanox are widely used and have been detected in many fatal …

The general population is exposed to the genotoxic carcinogen glycidol via food containing
refined edible oils where glycidol is present in the form of fatty acid esters. In this study …

Glycidol fatty acid esters that are present in foods are degraded in vivo to the animal
carcinogen glycidol, which binds to the N‐terminal valine of hemoglobin (Hb) to form N‐(2, 3 …