HLA-G: an immune checkpoint molecule
ED Carosella, N Rouas-Freiss, D Tronik-Le Roux… - Advances in …, 2015 - Elsevier
HLA-G is a molecule that was first known to confer protection to the fetus from destruction by
the immune system of its mother, thus critically contributing to fetal–maternal tolerance. The …
the immune system of its mother, thus critically contributing to fetal–maternal tolerance. The …
HLA-G: at the interface of maternal–fetal tolerance
During pregnancy, semiallogeneic fetal extravillous trophoblasts (EVT) invade the uterine
mucosa without being rejected by the maternal immune system. Several mechanisms were …
mucosa without being rejected by the maternal immune system. Several mechanisms were …
HLA-E is a major ligand for the natural killer inhibitory receptor CD94/NKG2A
N Lee, M Llano, M Carretero… - Proceedings of the …, 1998 - National Acad Sciences
We previously showed that the availability of a nonamer peptide derived from certain HLA
class I signal sequences is a necessary requirement for the stabilization of endogenous HLA …
class I signal sequences is a necessary requirement for the stabilization of endogenous HLA …
Implications of the polymorphism of HLA-G on its function, regulation, evolution and disease association
The HLA-G gene displays several peculiarities that are distinct from those of classical HLA
class I genes. The unique structure of the HLA-G molecule permits a restricted peptide …
class I genes. The unique structure of the HLA-G molecule permits a restricted peptide …
Recognition of human histocompatibility leukocyte antigen (HLA)-E complexed with HLA class I signal sequence–derived peptides by CD94/NKG2 confers protection …
F Borrego, M Ulbrecht, EH Weiss, JE Coligan… - The Journal of …, 1998 - rupress.org
Human histocompatibility leukocyte antigen (HLA)-E is a nonclassical HLA class I molecule,
the gene for which is transcribed in most tissues. It has recently been reported that this …
the gene for which is transcribed in most tissues. It has recently been reported that this …
Mechanisms of MHC class I–restricted antigen processing
E Pamer, P Cresswell - Annual review of immunology, 1998 - annualreviews.org
▪ Abstract Classical class I molecules assemble in the endoplasmic reticulum (ER) with
peptides mostly generated from cytosolic proteins by the proteasome. The activity of the …
peptides mostly generated from cytosolic proteins by the proteasome. The activity of the …
HLA-E surface expression depends on binding of TAP-dependent peptides derived from certain HLA class I signal sequences
N Lee, DR Goodlett, A Ishitani, H Marquardt… - The Journal of …, 1998 - journals.aai.org
Previous studies showed that HLA-E was expressed in lymphoblastoid cell line (LCL)
721.221 cells, but surface expression was lacking. To determine the signals controlling …
721.221 cells, but surface expression was lacking. To determine the signals controlling …
The human major histocompatibility complex class Ib molecule HLA‐E binds signal sequence‐derived peptides with primary anchor residues at positions 2 and 9
V Braud, E Yvonne Jones… - European journal of …, 1997 - Wiley Online Library
Human histocompatibility leukocyte antigen E (HLA‐E) and mouse major histocompatibility
complex (MHC) class Ib antigen, Qa‐1, share the same substitutions at two normally …
complex (MHC) class Ib antigen, Qa‐1, share the same substitutions at two normally …
HLA-G expression in melanoma: a way for tumor cells to escape from immunosurveillance
P Paul, N Rouas-Freiss, I Khalil-Daher… - Proceedings of the …, 1998 - National Acad Sciences
Considering the well established role of nonclassical HLA-G class I molecules in inhibiting
natural killer (NK) cell function, the consequence of abnormal HLA-G expression in …
natural killer (NK) cell function, the consequence of abnormal HLA-G expression in …
Soluble HLA‐A,‐B,‐C and ‐G molecules induce apoptosis in T and NK CD8+ cells and inhibit cytotoxic T cell activity through CD8 ligation
There is convincing evidence that soluble HLA‐A,‐B,‐C (sHLA‐A,‐B,‐C) and soluble HLA‐G
(sHLA‐G) antigens can induce apoptosis in CD8+ activated T cells although there is scanty …
(sHLA‐G) antigens can induce apoptosis in CD8+ activated T cells although there is scanty …