[HTML][HTML] Advanced MALDI mass spectrometry imaging in pharmaceutical research and drug development
S Schulz, M Becker, MR Groseclose, S Schadt… - Current opinion in …, 2019 - Elsevier
Highlights•Ideal mass spectrometer for MALDI MSI would satisfy the '4S-criteria for
performance'(speed, specificity, spatial resolution and sensitivity).•Quantification MALDI MSI …
performance'(speed, specificity, spatial resolution and sensitivity).•Quantification MALDI MSI …
Quantitative mass spectrometry imaging of biological systems
D Unsihuay, D Mesa Sanchez… - Annual review of physical …, 2021 - annualreviews.org
Mass spectrometry imaging (MSI) is a powerful, label-free technique that provides detailed
maps of hundreds of molecules in complex samples with high sensitivity and subcellular …
maps of hundreds of molecules in complex samples with high sensitivity and subcellular …
Emerging computational methods in mass spectrometry imaging
Mass spectrometry imaging (MSI) is a powerful analytical technique that generates maps of
hundreds of molecules in biological samples with high sensitivity and molecular specificity …
hundreds of molecules in biological samples with high sensitivity and molecular specificity …
Surface‐assisted laser desorption/ionization mass spectrometry imaging: A review
In the last decades, surface‐assisted laser desorption/ionization mass spectrometry (SALDI‐
MS) has attracted increasing interest due to its unique capabilities, achievable through the …
MS) has attracted increasing interest due to its unique capabilities, achievable through the …
[HTML][HTML] Cellular resolution in clinical MALDI mass spectrometry imaging: the latest advancements and current challenges
K Ščupáková, B Balluff, C Tressler… - Clinical Chemistry and …, 2020 - degruyter.com
Mass spectrometry (MS) is the workhorse of metabolomics, proteomics and lipidomics. Mass
spectrometry imaging (MSI), its extension to spatially resolved analysis of tissues, is a …
spectrometry imaging (MSI), its extension to spatially resolved analysis of tissues, is a …
Nanospray desorption electrospray ionization (Nano-DESI) mass spectrometry imaging with high ion mobility resolution
Untargeted separation of isomeric and isobaric species in mass spectrometry imaging (MSI)
is challenging. The combination of ion mobility spectrometry (IMS) with MSI has emerged as …
is challenging. The combination of ion mobility spectrometry (IMS) with MSI has emerged as …
[HTML][HTML] Mass spectrometry imaging in drug distribution and drug metabolism studies–Principles, applications and perspectives
JR Granborg, AM Handler, C Janfelt - TrAC Trends in Analytical Chemistry, 2022 - Elsevier
New mass spectrometry imaging (MSI) techniques are gaining importance in various stages
of the drug discovery and development chain as well as in more fundamental studies of drug …
of the drug discovery and development chain as well as in more fundamental studies of drug …
Spatial analysis of drug absorption, distribution, metabolism, and toxicology using mass spectrometry imaging
ML Spruill, M Maletic-Savatic, H Martin, F Li… - Biochemical …, 2022 - Elsevier
Mass spectrometry imaging (MSI) is emerging as a powerful analytical tool for detection,
quantification, and simultaneous spatial molecular imaging of endogenous and exogenous …
quantification, and simultaneous spatial molecular imaging of endogenous and exogenous …
Weakly supervised identification and localization of drug fingerprints based on label-free hyperspectral CARS microscopy
Understanding drug fingerprints in complex biological samples is essential for the
development of a drug. Hyperspectral coherent anti-Stokes Raman scattering (HS-CARS) …
development of a drug. Hyperspectral coherent anti-Stokes Raman scattering (HS-CARS) …
Morphometric cell classification for single‐cell MALDI‐mass spectrometry imaging
K Ščupáková, F Dewez, AK Walch… - Angewandte …, 2020 - Wiley Online Library
The large‐scale and label‐free molecular characterization of single cells in their natural
tissue habitat remains a major challenge in molecular biology. We present a method that …
tissue habitat remains a major challenge in molecular biology. We present a method that …