While skeletal muscle remodeling happens throughout life, diseases that result in its
dysfunction are accountable for many deaths. Indeed, skeletal muscle is exceptionally …

Muscular dystrophies (MDs) encompass a wide variety of inherited disorders that are
characterized by loss of muscle tissue associated with a progressive reduction in muscle …

Abstract The C57BL/10ScSn-Dmd mdx/J (BL10-mdx) mouse has been the most commonly
used model for Duchenne muscular dystrophy (DMD) for decades. Their muscle dysfunction …

Background Diabetic myopathy involves hyperglycaemia and inflammation that causes
skeletal muscle dysfunction; however, the potential cellular mechanisms that occur between …

Transforming Growth Factor β (TGF-β) is involved in fibrosis as well as the regulation of
muscle mass, and contributes to the progressive pathology of muscle wasting disorders …

Sarcoglycanopathies are a group of recessive limb-girdle muscular dystrophies,
characterized by progressive muscle weakness. Sarcoglycan deficiency produces instability …

Muscle fibrosis represents the end stage consequence of different diseases, among which
muscular dystrophies, leading to severe impairment of muscle functions. Muscle fibrosis …

Myostatin was identified more than 20 years ago as a negative regulator of muscle mass in
mice and cattle. Since then, a wealth of studies have uncovered the potential involvement of …

Diabetic myopathy involves hyperglycemia, oxidative stress, and inflammation. However, the
role of hypercholesterolemia-induced inflammation-mediated pathological mechanisms …

Muscular dystrophies are genetic diseases characterized by chronic inflammation and
fibrosis. Macrophages are immune cells that sustain muscle regeneration upon acute injury …